Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CCND2 | P30279 | 1/20 | 0.42 |
| ▸ | CCND3 | P30281 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3286379 | 0.91 | EGFR (0.57) | SYKFLT3PDGFRBPDGFRAEGFR | |
| SCHEMBL3285976 | 0.89 | PDGFRB (0.50) | SYKFLT3PDGFRBPDGFRAEGFR | |
| SCHEMBL3279674 | 0.89 | FLT3 (0.48) | SYKFLT3EGFRALKFGFR4 | |
| SCHEMBL3282662 | 0.88 | FLT3 (0.49) | SYKFLT3ALKFGFR4JAK2 | |
| SCHEMBL3282602 | 0.88 | SYK (0.58) | SYKFLT3PDGFRBPDGFRAEGFR | |
| SCHEMBL13387229 | 0.86 | FLT3 (0.49) | SYKFLT3EGFRALKFGFR4 | |
| SCHEMBL3279464 | 0.85 | PDGFRB (0.45) | SYKFLT3PDGFRBPDGFRA | |
| SCHEMBL1041462 | 0.84 | SYK (0.51) | SYKFLT3EGFRALKFGFR4 | |
| SCHEMBL3280304 | 0.84 | KDR (0.43) | SYKPDGFRBPDGFRAEGFRFGFR1 | |
| SCHEMBL3281003 | 0.84 | PDGFRB (0.40) | SYKPDGFRBPDGFRAEGFRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7705004-B2 | Protein kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| WO-2009026107-A1 | PROTEIN KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-02-26 | — | — | WO | disclosed |
| US-20090054425-A1 | PROTEIN KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054425-A1 | PROTEIN KINASE INHIBITORS | SYK, JAK2, BTK | SYK 1/4885FLT3 172/4885PDGFRB 388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.