⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3280888 | 1.00 | — | — | |
| SCHEMBL8390526 | 0.78 | GRIK1 (0.36) | — | |
| SCHEMBL2330443 | 0.71 | — | — | |
| SCHEMBL5986649 | 0.71 | — | — | |
| SCHEMBL5986657 | 0.71 | — | — | |
| SCHEMBL1137959 | 0.69 | — | — | |
| SCHEMBL1137962 | 0.69 | — | — | |
| SCHEMBL10779349 | 0.67 | KDM4E (0.33) | — | |
| SCHEMBL263012 | 0.63 | — | — | |
| SCHEMBL513636 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE41253-E1 | Antineoplastic combinations | WYETH (US) | 2010-04-20 | — | — | US | claimed |
| EP-1585479-A2 | SYNTHESIS OF 4AMINO-2-BUTENOYL CHLORIDES AND THEIR USE IN THE PREPARATION OF 3-CYANO QUINOLINES | Wyeth (US) | 2005-10-19 | — | — | EP | claimed |
| US-20040162442-A1 | Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines | WYETH (US) | 2004-08-19 | — | — | US | claimed |
| WO-2004066919-A2 | SYNTHESIS OF 4AMINO-2-BUTENOYL CHLORIDES AND THEIR USE IN THE PREPARATION OF 3-CYANO QUINOLINES | WYETH (US) | 2004-08-12 | — | — | WO | claimed |
| CN-116789694-A | Use of tris (trimethylsilyl) borate as hydroxyl, carboxyl and amino, and amide protecting agent | 衢州科峰新材料有限公司 | 2023-09-22 | — | — | CN | disclosed |
| US-9758471-B2 | Process for the preparation of 4-dimethylaminocrotonic acid | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2017-09-12 | — | — | US | disclosed |
| US-20170107172-A1 | PROCESS FOR THE PREPARATION OF 4-DIMETHYLAMINOCROTONIC ACID | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2017-04-20 | — | — | US | disclosed |
| EP-3148977-A1 | PROCESS FOR THE PREPARATION OF 4-DIMETHYLAMINOCROTONIC ACID | Sun Pharmaceutical Industries Ltd (IN) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015186065-A1 | PROCESS FOR THE PREPARATION OF 4-DIMETHYLAMINOCROTONIC ACID | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2015-12-10 | — | — | WO | disclosed |
| US-7126025-B2 | Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines | WYETH (US) | 2006-10-24 | — | — | US | disclosed |
| EP-1585479-A2 | SYNTHESIS OF 4AMINO-2-BUTENOYL CHLORIDES AND THEIR USE IN THE PREPARATION OF 3-CYANO QUINOLINES | Wyeth (US) | 2005-10-19 | — | — | EP | disclosed |
| US-20040162442-A1 | Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines | WYETH (US) | 2004-08-19 | — | — | US | disclosed |
| WO-2004066919-A2 | SYNTHESIS OF 4AMINO-2-BUTENOYL CHLORIDES AND THEIR USE IN THE PREPARATION OF 3-CYANO QUINOLINES | WYETH (US) | 2004-08-12 | — | — | WO | disclosed |
| EP-1171440-B1 | SUBSTITUTED-3-CYANO-[1.7],[1.5], AND [1.8]-NAPHTHYRIDINE INHIBITORS OF TYROSINE KINASES | WYETH CORP (US) | 2004-04-14 | — | — | EP | disclosed |
| US-6548496-B2 | Anticancer agents | AMERICAN CYANAMID COMPANY | 2003-04-15 | — | — | US | disclosed |
| US-20020165229-A1 | Substituted 3-cyano-[1.7], [1.5], and [1.8] naphthyridine inhibitors of tyrosine kinases | AMERICAN CYANAMID COMPANY | 2002-11-07 | — | — | US | disclosed |
| US-6355636-B1 | ENZYME INHIBITORS | AMERICAN CYANAMID COMPANY | 2002-03-12 | — | — | US | disclosed |
| EP-1171440-A1 | SUBSTITUTED-3-CYANO-[1.7],[1.5], AND [1.8]-NAPHTHYRIDINE INHIBITORS OF TYROSINE KINASES | American Cyanamid Company (US) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000066583-A1 | SUBSTITUTED 3-CYANO-[1.7], [1.5], AND [1.8]-NAPHTHYRIDINE INHIBITORS OF TYROSINE KINASES | AMERICAN CYANAMID COMPANY (US) | 2000-11-09 | — | — | WO | disclosed |