Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL3283939 | 0.98 | PDE4B (0.58) | PDE4BPDE4D | |
| SCHEMBL3284167 | 0.98 | PDE4B (0.58) | PDE4BPDE4D | |
| SCHEMBL3282008 | 0.96 | PDE4B (0.61) | PDE4BPDE4D | |
| Bromide SCHEMBL3285815 | 0.95 | PDE4B (0.60) | PDE4BPDE4D | |
| Hydrochloric Acid SCHEMBL3282426 | 0.95 | PDE4B (0.60) | PDE4BPDE4D | |
| Phosphoric Acid SCHEMBL3282705 | 0.94 | PDE4B (0.58) | PDE4BPDE4D | |
| SCHEMBL3281712 | 0.94 | PDE4B (0.59) | PDE4BPDE4D | |
| SCHEMBL3290151 | 0.94 | PDE4B (0.54) | PDE4BPDE4D | |
| SCHEMBL5173840 | 0.93 | PDE4B (0.58) | PDE4BPDE4D | |
| SCHEMBL4938151 | 0.93 | PDE4B (0.58) | PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709497-B2 | Pyrazolo[3,4-b]pyridine compound, and its use as a PDE4 inhibitor | GLAXO GROUP LIMITED (GB) | 2010-05-04 | — | — | US | claimed |