Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10289270 | 0.85 | POLB (0.47) | POLBTSHRTP53THRBMAPT | |
| SCHEMBL281987 | 0.72 | POLB (0.40) | POLBTSHRTP53THRBMAPT | |
| SCHEMBL19562199 | 0.65 | POLB (0.49) | POLBTSHRTHRBMAPTMEN1 | |
| SCHEMBL281805 | 0.64 | SCN9A (0.61) | POLBTSHRTP53THRBMEN1 | |
| SCHEMBL280850 | 0.62 | SCN9A (0.46) | POLBTP53THRB | |
| SCHEMBL280798 | 0.61 | POLB (0.47) | POLBTSHRTP53THRBMAPT | |
| SCHEMBL280676 | 0.59 | SCN9A (0.58) | POLBTSHRTHRBMAPT | |
| SCHEMBL2305385 | 0.59 | SCN9A (0.53) | POLBTSHRTP53THRB | |
| SCHEMBL9135817 | 0.57 | POLB (0.69) | POLBTSHRTP53MAPTMEN1 | |
| SCHEMBL1063418 | 0.57 | NPSR1 (0.71) | POLBTSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428515-A1 | Spiro-oxindole compounds and their uses as therapeutic agents | Xenon Pharmaceuticals Inc. (CA) | 2012-03-14 | — | — | EP | disclosed |
| EP-1888595-B1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC (CA) | 2012-02-01 | — | — | EP | disclosed |