Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 15/20 | 0.50 |
| ▸ | CCR3 | P51677 | 15/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.50 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3283132 | 1.00 | HRH1 (0.50) | HRH1CCR3KCNH2CCR1EPHX2 | |
| SCHEMBL3282963 | 0.90 | HRH1 (0.48) | HRH1CCR3KCNH2CNR2 | |
| SCHEMBL3282974 | 0.90 | HRH1 (0.48) | HRH1CCR3KCNH2CNR2 | |
| SCHEMBL3286028 | 0.89 | HRH1 (0.46) | HRH1CCR3KCNH2CNR2 | |
| SCHEMBL3286021 | 0.89 | HRH1 (0.46) | HRH1CCR3KCNH2CNR2 | |
| SCHEMBL6648874 | 0.83 | HRH1 (0.54) | HRH1CCR3KCNH2 | |
| SCHEMBL1929697 | 0.83 | HRH1 (0.54) | HRH1CCR3KCNH2 | |
| SCHEMBL31743061 | 0.80 | KAT2B (0.52) | — | |
| SCHEMBL31743073 | 0.80 | KAT2B (0.52) | — | |
| SCHEMBL3282640 | 0.78 | HRH1 (0.72) | HRH1CCR3KCNH2CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709500-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2010-05-04 | — | — | US | disclosed |
| US-20050107428-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2005-05-19 | — | — | US | disclosed |
| EP-1478624-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003068743-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107428-A1 | Chemical compounds | CCR10, CCR3, CXCR5 | HRH1 33/4885CCR3 2/4885KCNH2 862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.