Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.54 |
| ▸ | PLK4 | O00444 | 2/20 | 0.53 |
| ▸ | PLK1 | P53350 | 2/20 | 0.53 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.53 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 5/20 | 0.52 |
| ▸ | DHFR | P00374 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.50 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.50 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3283782 | 1.00 | NPC1 (0.56) | NPC1MDM2PLK4PLK1MAP3K7 | |
| SCHEMBL3285325 | 0.89 | FLT3 (0.68) | NPC1MDM2FLT3 | |
| SCHEMBL3284152 | 0.89 | FLT3 (0.68) | NPC1MDM2FLT3 | |
| SCHEMBL3283170 | 0.78 | FLT3 (0.76) | NPC1MDM2PLK4PLK1MAP3K7 | |
| SCHEMBL3283166 | 0.78 | FLT3 (0.76) | NPC1MDM2PLK4PLK1MAP3K7 | |
| SCHEMBL3283165 | 0.78 | FLT3 (0.76) | NPC1MDM2PLK4PLK1MAP3K7 | |
| SCHEMBL14521057 | 0.76 | PDPK1 (0.54) | NPC1MDM2PLK4PLK1FLT3 | |
| SCHEMBL3282581 | 0.75 | FLT3 (0.76) | NPC1PLK4PLK1MAP3K7TAB1 | |
| SCHEMBL3282584 | 0.75 | FLT3 (0.76) | NPC1PLK4PLK1MAP3K7TAB1 | |
| SCHEMBL14521088 | 0.74 | FLT3 (0.57) | NPC1MDM2PLK4PLK1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7714146-B2 | Azulene-oxindole compounds as multiple-kinase inhibitors and useful as anticancer agents | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2010-05-11 | — | — | US | disclosed |
| US-7714146-B2 | Azulene-oxindole compounds as multiple-kinase inhibitors and useful as anticancer agents | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2010-05-11 | — | — | US | disclosed |
| US-20080125590-A1 | Azulene compounds | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2008-05-29 | — | — | US | disclosed |
| US-20080125590-A1 | Azulene compounds | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2008-05-29 | — | — | US | disclosed |
| EP-1918277-A2 | Azulene compounds | Industrial Technology Research Institute (TW) | 2008-05-07 | — | — | EP | disclosed |
| EP-1918277-A2 | Azulene compounds | Industrial Technology Research Institute (TW) | 2008-05-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125590-A1 | Azulene compounds | AZI2, PRMT5, BRCA1 | NPC1 1869/4885MDM2 1321/4885PLK4 4237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.