Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 5/20 | 0.76 |
| ▸ | CA1 | P00915 | 11/20 | 0.74 |
| ▸ | CA2 | P00918 | 11/20 | 0.74 |
| ▸ | CA9 | Q16790 | 5/20 | 0.74 |
| ▸ | CA12 | O43570 | 4/20 | 0.74 |
| ▸ | CA4 | P22748 | 3/20 | 0.74 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.74 |
| ▸ | GAB1 | Q13480 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL283044 | 1.00 | AKT1 (0.76) | AKT1CA1CA2CA9CA12 | |
| SCHEMBL10108711 | 1.00 | AKT1 (0.76) | AKT1CA1CA2CA9CA12 | |
| SCHEMBL11893060 | 0.87 | CA1 (0.81) | AKT1CA1CA2CA9CA12 | |
| SCHEMBL282503 | 0.86 | AKT1 (1.00) | AKT1CA1CA2CA9CA12 | |
| SCHEMBL11893071 | 0.85 | AKT1 (1.00) | AKT1 | |
| SCHEMBL282468 | 0.85 | AKT1 (1.00) | AKT1 | |
| SCHEMBL282462 | 0.84 | AKT1 (1.00) | AKT1GAB1 | |
| SCHEMBL11893069 | 0.84 | AKT1 (1.00) | AKT1GAB1 | |
| SCHEMBL31058615 | 0.84 | AKT1 (0.98) | AKT1 | |
| SCHEMBL282883 | 0.84 | AKT1 (0.76) | AKT1CA1CA2CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428504-A1 | Small molecule inhibitors of the pleckstrin homology domain and method for using same | The Board of Regents of the University of Texas System (US) | 2012-03-14 | — | — | EP | disclosed |