Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 15/20 | 0.76 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3286653 | 0.89 | SLC6A2 (0.77) | SLC6A2SLC6A4 | |
| SCHEMBL3288920 | 0.87 | SLC6A2 (0.74) | SLC6A2SLC6A4NPC1PKMRAB9A | |
| SCHEMBL3287539 | 0.86 | SLC6A2 (0.70) | SLC6A2SLC6A4 | |
| SCHEMBL3294850 | 0.86 | SLC6A2 (1.00) | SLC6A2SLC6A4HTT | |
| SCHEMBL3287640 | 0.85 | SLC6A2 (0.74) | SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL3288145 | 0.85 | SLC6A2 (0.98) | SLC6A2SLC6A4HTT | |
| SCHEMBL3286958 | 0.84 | SLC6A2 (0.73) | SLC6A2SLC6A4 | |
| SCHEMBL3289993 | 0.79 | SLC6A2 (0.74) | SLC6A2SLC6A4 | |
| SCHEMBL3292429 | 0.79 | SLC6A2 (0.76) | SLC6A2SLC6A4 | |
| SCHEMBL3285452 | 0.77 | SLC6A2 (0.77) | SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718652-B2 | Substituted benzothiadiazinedioxide derivatives and methods of their use | WYETH LLC (US) | 2010-05-18 | — | — | US | disclosed |
| US-20080161295-A1 | SUBSTITUTED BENZOTHIADIAZINEDIOXIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-07-03 | — | — | US | disclosed |
| WO-2008073958-A2 | SUBSTITUTED BENZOTHIADIAZINEDIOXIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161295-A1 | SUBSTITUTED BENZOTHIADIAZINEDIOXIDE DERIVATIVES AND METHODS OF THEIR USE | SLC6A2, SLC6A4, DBH | SLC6A2 1/4885SLC6A4 2/4885HTT 491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.