Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 3/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3146466 | 1.00 | MEN1 (0.61) | MEN1MAPTKMT2ATDP1HPGD | |
| SCHEMBL13256846 | 1.00 | MEN1 (0.61) | MEN1MAPTKMT2ATDP1HPGD | |
| SCHEMBL5674718 | 1.00 | MEN1 (0.61) | MEN1MAPTKMT2ATDP1HPGD | |
| SCHEMBL5674716 | 1.00 | MEN1 (0.61) | MEN1MAPTKMT2ATDP1HPGD | |
| SCHEMBL7836423 | 0.92 | HPGD (0.56) | MEN1MAPTKMT2ATDP1HPGD | |
| SCHEMBL16282035 | 0.92 | HPGD (0.56) | MEN1MAPTKMT2ATDP1HPGD | |
| SCHEMBL3284122 | 0.91 | MAPT (0.59) | MEN1MAPTKMT2ATDP1HPGD | |
| SCHEMBL6970021 | 0.88 | MEN1 (0.50) | MEN1MAPTKMT2ATDP1HPGD | |
| SCHEMBL6970017 | 0.88 | MEN1 (0.50) | MEN1MAPTKMT2ATDP1HPGD | |
| SCHEMBL7828846 | 0.88 | HPGD (0.49) | MEN1MAPTKMT2ATDP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309582-B2 | Small molecule Bcl-Xl/Bcl-2 binding inhibitors | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-11-13 | — | — | US | disclosed |
| US-20100168184-A1 | SMALL MOLECULE BCL-X1/BCL-2 BINDING INHIBITORS | NATIONAL INSTITUTES OF HEALTH | 2010-07-01 | — | — | US | disclosed |
| US-7714005-B2 | Small molecule Bcl-xL/Bcl-2 binding inhibitors | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-05-11 | — | — | US | disclosed |
| US-7566787-B2 | Small molecule cyclin D1 ablative agents | THE OHIO STATE UNIVERSITY (US) | 2009-07-28 | — | — | US | disclosed |
| US-20060252802-A1 | Small molecule cyclin D1 ablative agents | NIH - DEITR | 2006-11-09 | — | — | US | disclosed |
| US-20060252801-A1 | Small molecule Bcl-xL/Bcl-2 binding inhibitors | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2006-11-09 | — | — | US | disclosed |
| WO-2006069186-A2 | SMALL MOLECULE BCL-XL/BCL-2 BINDING INHIBITORS | THE OHIO STATE RESEARCH FOUNDATION (US) | 2006-06-29 | — | — | WO | disclosed |
| WO-2006069217-A2 | SMALL MOLECULE CYCLIN D1 ABLATIVE AGENTS | THE OHIO STATE RESEARCH FOUNDATION (US) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252801-A1 | Small molecule Bcl-xL/Bcl-2 binding inhibitors | BCL2L1, BCL2, BCL2L2 | MEN1 2209/4885MAPT 4165/4885KMT2A 2158/4885 |
| US-20060252802-A1 | Small molecule cyclin D1 ablative agents | CDK4, CCNK, CCNA1 | MEN1 3068/4885MAPT 4563/4885KMT2A 504/4885 |
| US-20100168184-A1 | SMALL MOLECULE BCL-X1/BCL-2 BINDING INHIBITORS | BCL2, BCL2L1, BCL2A1 | MEN1 2017/4885MAPT 4332/4885KMT2A 2299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.