Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1B | O75688 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | PPP1CC | P36873 | 2/20 | 0.50 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LGMN | Q99538 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15712143 | 0.90 | PPM1B (0.53) | PPM1BPTPN1PPP1CCHSD11B1MAPT | |
| SCHEMBL30242901 | 0.83 | PPM1B (0.45) | PPM1BPTPN1PPP1CCSMYD3HSD11B1 | |
| SCHEMBL26015242 | 0.83 | PPM1B (0.45) | PPM1BPTPN1PPP1CCSMYD3HSD11B1 | |
| SCHEMBL24198225 | 0.83 | PPM1B (0.45) | PPM1BPTPN1PPP1CCSMYD3HSD11B1 | |
| SCHEMBL34472262 | 0.82 | PPM1B (0.47) | PPM1BPTPN1PPP1CCSMYD3MAPT | |
| SCHEMBL31184507 | 0.82 | PPM1B (0.47) | PPM1BPTPN1PPP1CCSMYD3MAPT | |
| SCHEMBL360031 | 0.82 | PPM1B (0.47) | PPM1BPTPN1PPP1CCHSD11B1MAPT | |
| SCHEMBL5791356 | 0.82 | PPM1B (0.50) | PPM1BPTPN1PPP1CCHSD11B1MAPT | |
| SCHEMBL3985705 | 0.82 | PPM1B (0.50) | PPM1BPTPN1PPP1CCHSD11B1MAPT | |
| SCHEMBL25467328 | 0.82 | PPM1B (0.50) | PPM1BPTPN1PPP1CCHSD11B1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2407452-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme | Abbott Laboratories (US) | 2012-01-18 | — | — | EP | disclosed |