Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3288961 | 0.92 | KDM4E (0.54) | GAAKDM4ETRPV1EPHX2ALDH1A1 | |
| SCHEMBL3290805 | 0.91 | KDM4E (0.47) | GAAKDM4EEPHX2NPC1RAB9A | |
| SCHEMBL3289514 | 0.91 | GAA (0.47) | GAAKDM4ETRPV1POLBALDH1A1 | |
| SCHEMBL3289504 | 0.90 | GAA (0.60) | GAAKDM4ETRPV1EPHX2POLB | |
| SCHEMBL5144167 | 0.88 | KDM4E (0.48) | GAAKDM4EEPHX2MAPTCHRM3 | |
| SCHEMBL5144288 | 0.86 | KDM4E (0.46) | GAAKDM4ETRPV1 | |
| SCHEMBL4072296 | 0.84 | GAA (0.62) | GAAKDM4ETRPV1EPHX2POLB | |
| SCHEMBL3288593 | 0.83 | SMN1; SMN2 (0.44) | GAAKDM4EEPHX2POLBALDH1A1 | |
| SCHEMBL13329150 | 0.82 | GAA (0.50) | GAAKDM4EPOLBALDH1A1TSHR | |
| SCHEMBL3290350 | 0.82 | KDM4E (0.50) | GAAKDM4ENPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723358-B2 | Aroyl-O-piperidine derivatives for the treatment of diabetes-related problems | MERCK PATENT GMBH (DE) | 2010-05-25 | — | — | US | claimed |