Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 11/20 | 0.39 |
| ▸ | PNP | P00491 | 7/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2909042 | 0.83 | HDAC6 (0.44) | HPRT1PNP | |
| Lb80317 SCHEMBL2905773 | 0.80 | POLB (0.39) | HPRT1PNPCDK1CCNB1CCNE1 | |
| SCHEMBL2908457 | 0.79 | CYP2C19 (0.37) | HPRT1PNP | |
| SCHEMBL2911611 | 0.79 | FGFR1 (0.53) | — | |
| SCHEMBL3291258 | 0.79 | POLB (0.38) | HPRT1PNPCDK1CCNB1CCNE1 | |
| SCHEMBL2906272 | 0.77 | HPRT1 (0.40) | HPRT1CDK1CCNB1CCNE1CDK2 | |
| SCHEMBL2911779 | 0.77 | CCNE1 (0.36) | HPRT1PNPCDK1CCNB1CCNE1 | |
| SCHEMBL4270165 | 0.77 | CCNE1 (0.36) | HPRT1PNPCDK1CCNB1CCNE1 | |
| SCHEMBL3293421 | 0.76 | PNP (0.36) | HPRT1PNPCDK1CCNB1CCNE1 | |
| SCHEMBL3293399 | 0.76 | PNP (0.36) | HPRT1PNPCDK1CCNB1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605147-B2 | Acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same | LG LIFE SCIENCES LTD. (KR) | 2009-10-20 | — | — | US | claimed |
| CN-100347185-C | Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same | LG LIFE SCIENCE CO LTD (KR) | 2007-11-07 | — | — | CN | claimed |
| US-20060293284-A1 | Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same | CHO DONG-GYU | 2006-12-28 | — | — | US | claimed |
| US-20060052346-A1 | Nucleoside phosphonate derivatives useful in the treatment of HIV infections | LG LIFE SCIENCES LTD. (KR) | 2006-03-09 | — | — | US | claimed |
| CN-1487949-A | Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same | ��ʽ����LG������ѧ | 2004-04-07 | — | — | CN | claimed |
| US-20040063668-A1 | Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same | LG LIFE SCIENCES LTD. (KR) | 2004-04-01 | — | — | US | claimed |
| US-7723319-B2 | Acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same | LG LIFE SCIENCES LTD. (KR) | 2010-05-25 | — | — | US | disclosed |
| CN-1921867-B | Nucleoside phosphonate derivatives for the treatment of HIV infection | LG LIFE SCIENCES LTD | 2010-05-05 | — | — | CN | disclosed |
| US-7605147-B2 | Acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same | LG LIFE SCIENCES LTD. (KR) | 2009-10-20 | — | — | US | disclosed |
| CN-100347185-C | Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same | LG LIFE SCIENCE CO LTD (KR) | 2007-11-07 | — | — | CN | disclosed |
| US-7157448-B2 | Acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same | LG LIFE SCIENCES LTD. (KR) | 2007-01-02 | — | — | US | disclosed |
| US-20060293284-A1 | Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same | CHO DONG-GYU | 2006-12-28 | — | — | US | disclosed |
| US-20060052346-A1 | Nucleoside phosphonate derivatives useful in the treatment of HIV infections | LG LIFE SCIENCES LTD. (KR) | 2006-03-09 | — | — | US | disclosed |
| CN-1487949-A | Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same | ��ʽ����LG������ѧ | 2004-04-07 | — | — | CN | disclosed |
| US-20040063668-A1 | Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same | LG LIFE SCIENCES LTD. (KR) | 2004-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052346-A1 | Nucleoside phosphonate derivatives useful in the treatment of HIV infections | PNP, TYMP, ENTPD5 | HPRT1 5/4885PNP 1/4885CDK1 548/4885 |
| US-20060293284-A1 | Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same | PNP, ITPA, MTAP | HPRT1 34/4885PNP 1/4885CDK1 452/4885 |
| US-20040063668-A1 | Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same | PNP, ITPA, MTAP | HPRT1 34/4885PNP 1/4885CDK1 452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.