Phosphine

Phosphine

SCHEMBL3292154

COS(=O)(=O)C(F)(F)F.P

nearest known ligand 0.37

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Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
USP2 O75604 1/20 0.37
TSHR P16473 1/20 0.37
CA1 P00915 2/20 0.35
CA2 P00918 2/20 0.35
CA7 P43166 1/20 0.35
CA13 Q8N1Q1 1/20 0.35
F2 P00734 1/20 0.34
PRSS1 P07477 1/20 0.34
PRSS2 P07478 1/20 0.34
PRSS3 P35030 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16998538 0.97
SCHEMBL38490 0.97
SCHEMBL1332156 0.97
SCHEMBL2744387 0.97 USP2 (0.39) USP2TSHRCA1CA2CA7
SCHEMBL31247237 0.97
SCHEMBL29105515 0.94
Charcoal, Activated SCHEMBL3243670 0.94 USP2 (0.37) USP2TSHRCA1CA2CA7
SCHEMBL1377186 0.94 USP2 (0.37) USP2TSHRCA1CA2CA7
SCHEMBL8000366 0.94 USP2 (0.37) USP2TSHRCA1CA2CA7
Hydrogen Sulfide SCHEMBL7995255 0.94 USP2 (0.37) USP2TSHRCA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7728091-B2 Polymerization of phosphaalkenes THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2010-06-01 US disclosed
US-20060270805-A1 Polymerization of phosphaalkenes UNIVERSITY OF BRITISH COLUMBIA, THE (CA) 2006-11-30 US disclosed
WO-2004055098-A2 POLYMERIZATION OF PHOSPHAALKENES THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2004-07-01 WO disclosed
US-5852198-A Wittig reagents and method for preparing α,β-unsaturated phosphonates MEDICHEM RESEARCH, INC. (US) 1998-12-22 US disclosed
WO-1997036909-A1 WITTIG REAGENTS AND METHOD FOR PREPARING α,β-UNSATURATED PHOSPHONATES MEDICHEM RESEARCH, INC. (US) 1997-10-09 WO disclosed