Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5878384 | 1.00 | — | — | |
| SCHEMBL4082552 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL10887390 | 0.94 | — | — | |
| Bromide SCHEMBL17026712 | 0.77 | — | — | |
| SCHEMBL4457305 | 0.73 | — | — | |
| SCHEMBL28405773 | 0.71 | — | — | |
| SCHEMBL6154815 | 0.71 | — | — | |
| SCHEMBL2930698 | 0.71 | — | — | |
| SCHEMBL6472919 | 0.70 | — | — | |
| Bromide SCHEMBL8820336 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4563479-A | PROPHYLAXIS OR THERAPY | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYAR RT (HU) | 1986-01-07 | — | — | US | claimed |
| US-20180042899-A1 | Method of Treating Transplant Rejection and Autoimmune Diseases | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-15 | — | — | US | disclosed |
| US-20140050694-A1 | Method of Treating Transplant Rejection and Autoimmune Diseases | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2014-02-20 | — | — | US | disclosed |
| US-7718386-B1 | Methods for the diagnosis of diabetes | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-05-18 | — | — | US | disclosed |
| US-20100055675-A1 | METHOD FOR DETECTING MEASLES VIRUS, MEMBRANE ASSAY TEST DEVICE, AND MEMBRANE ASSAY TEST KIT | SYSMEX CORPORATION (JP) | 2010-03-04 | — | — | US | disclosed |
| US-20080160508-A1 | ASSAY METHOD AND ASSAY KIT FOR VIRUS RESPIRATORY INFECTION | SYSMEX CORPORATION (JP) | 2008-07-03 | — | — | US | disclosed |
| EP-0547164-B1 | METHODS FOR THE DIAGNOSIS AND TREATMENT OF DIABETES | UNIV CALIFORNIA (US) | 2004-06-09 | — | — | EP | disclosed |
| US-20020131963-A1 | METHODS AND COMPOSITIONS FOR TREATING TYPE I DIABETES USING GLUTAMIC ACID DECARBOXYLASE | BAEKKESKOV STEINUNN (US) | 2002-09-19 | — | — | US | disclosed |
| US-5512447-A | Methods for the diagnosis and treatment of diabetes | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-04-30 | — | — | US | disclosed |
| EP-0547164-A4 | — | — | 1994-01-26 | — | — | EP | disclosed |
| EP-0547164-A1 | METHODS FOR THE DIAGNOSIS AND TREATMENT OF DIABETES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1993-06-23 | — | — | EP | disclosed |
| WO-1992004632-A1 | METHODS FOR THE DIAGNOSIS AND TREATMENT OF DIABETES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1992-03-19 | — | — | WO | disclosed |