⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10702855 | 0.95 | CYP19A1 (0.40) | — | |
| SCHEMBL318859 | 0.93 | CYP19A1 (0.42) | — | |
| SCHEMBL1245099 | 0.90 | — | — | |
| SCHEMBL3296993 | 0.78 | SCN1A (0.57) | — | |
| SCHEMBL3297217 | 0.78 | SCN1A (0.42) | — | |
| SCHEMBL1928919 | 0.77 | — | — | |
| SCHEMBL114185 | 0.75 | — | — | |
| SCHEMBL19041418 | 0.75 | CYP19A1 (0.40) | — | |
| SCHEMBL12986568 | 0.74 | CYP19A1 (0.42) | — | |
| SCHEMBL13885160 | 0.73 | CYP19A1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110627832-A | Preparation method for synthesizing tenofovir alafenamide by oxidation method | 江西农业大学 | 2019-12-31 | — | — | CN | claimed |
| CN-110627832-A | Preparation method for synthesizing tenofovir alafenamide by oxidation method | 江西农业大学 | 2019-12-31 | — | — | CN | disclosed |
| US-7727434-B2 | Membranes and methods of treating membranes | GENERAL ELECTRIC COMPANY (US) | 2010-06-01 | — | — | US | disclosed |
| US-20070039874-A1 | Membranes and methods of treating membranes | GENERAL ELECTRIC COMPANY | 2007-02-22 | — | — | US | disclosed |
| US-20040138185-A1 | Process for the preparation of 3-glutamido bile ester derivatives using n-prtotected methyl proglutamate | BROCCHETTA MARINO | 2004-07-15 | — | — | US | disclosed |
| EP-1358201-A1 | A PROCESS FOR THE PREPARATION OF 3-GLUTAMIDO BILE ESTER DERIVATIVES USING N-PROTECTED METHYL PYROGLUTAMATE | BRACCO IMAGING S.p.A. (IT) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002068449-A1 | A PROCESS FOR THE PREPARATION OF 3-GLUTAMIDO BILE ESTER DERIVATIVES USING N-PRTOTECTED METHYL PROGLUTAMATE | BRACCO IMAGING S.P.A. (IT) | 2002-09-06 | — | — | WO | disclosed |
| US-3948971-A | N-protected-α-amino acid compounds | MERCK & CO., INC. (US) | 1976-04-06 | — | — | US | disclosed |