Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 0.64 |
| ▸ | CDK9 | P50750 | 14/20 | 0.64 |
| ▸ | CDK1 | P06493 | 10/20 | 0.56 |
| ▸ | CDK4 | P11802 | 10/20 | 0.56 |
| ▸ | CDK7 | P50613 | 10/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.56 |
| ▸ | CCNH | P51946 | 8/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.56 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.56 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.56 |
| ▸ | CASK | O14936 | 1/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.56 |
| ▸ | GSK3A | P49840 | 1/20 | 0.56 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.56 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.56 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3298930 | 0.88 | CDK2 (0.66) | CDK2CDK9CDK1CDK4CDK7 | |
| SCHEMBL3301221 | 0.85 | CDK2 (0.66) | CDK2CDK9CDK1CDK4CDK7 | |
| SCHEMBL3303030 | 0.83 | CDK2 (0.65) | CDK2CDK9CDK1CDK4CDK7 | |
| SCHEMBL3295952 | 0.78 | CDK2 (1.00) | CDK2CDK9CDK1CDK4CDK7 | |
| SCHEMBL3296793 | 0.78 | CDK2 (0.67) | CDK2CDK9CDK1CDK4CDK7 | |
| SCHEMBL23993161 | 0.74 | CDK1 (0.65) | CDK2CDK9CDK1CDK4CDK7 | |
| SCHEMBL19112171 | 0.74 | NPSR1 (0.60) | CDK2CDK9CDK1CDK4CDK7 | |
| SCHEMBL19112453 | 0.74 | NPSR1 (0.60) | CDK2CDK9CDK1CDK4CDK7 | |
| SCHEMBL19112169 | 0.73 | NPSR1 (0.70) | CDK2CDK9CDK1CDK4CDK7 | |
| SCHEMBL19112172 | 0.73 | NPSR1 (0.70) | CDK2CDK9CDK1CDK4CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139893-B1 | 2,6,9-SUBSTITUTED PURINE DERIVATIVES HAVING ANTIPROLIFERATIVE PROPERTIES | CYCLACEL LTD (GB) | 2013-06-19 | — | — | EP | claimed |
| US-8592581-B2 | Trisubstituted purine derivatives | CYCLACEL LIMITED (GB) | 2013-11-26 | — | — | US | disclosed |
| EP-2139893-B1 | 2,6,9-SUBSTITUTED PURINE DERIVATIVES HAVING ANTIPROLIFERATIVE PROPERTIES | CYCLACEL LTD (GB) | 2013-06-19 | — | — | EP | disclosed |
| US-20100093769-A1 | COMPOUNDS | CYCLACEL LIMITED (GB) | 2010-04-15 | — | — | US | disclosed |
| EP-2139893-A2 | 2,6,9-SUBSTITUTED PURINE DERIVATIVES HAVING ANTIPROLIFERATIVE PROPERTIES | Cyclacel Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008122767-A2 | 2, 6, 9-SUBSTITUTED PURINE DERIVATIVES HAVING ANTI PROLIFERATIVE PROPERTIES | CYCLACEL LIMITED (GB) | 2008-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093769-A1 | COMPOUNDS | CCR9, NPY1R, BCL9 | CDK2 1751/4885CDK9 57/4885CDK1 512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.