Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Trimethylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.31 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimethylammonium SCHEMBL3037482 | 0.98 | TDP1 (0.32) | TDP1GRIK1GRIK2LMNAALOX15 | |
| Trimethylammonium SCHEMBL444001 | 0.98 | TDP1 (0.32) | TDP1GRIK1GRIK2LMNAALOX15 | |
| Trimethylammonium SCHEMBL28049015 | 0.95 | TDP1 (0.31) | TDP1GRIK1GRIK2LMNAALOX15 | |
| Trimethylammonium SCHEMBL3296379 | 0.95 | TDP1 (0.31) | TDP1GRIK1GRIK2LMNAALOX15 | |
| SCHEMBL297211 | 0.91 | — | — | |
| SCHEMBL14982855 | 0.91 | — | — | |
| SCHEMBL297210 | 0.91 | — | — | |
| N,N-Dimethylethanaminium SCHEMBL446423 | 0.89 | CHRM1 (0.30) | — | |
| N,N-Dimethylethanaminium SCHEMBL3024639 | 0.89 | CHRM1 (0.30) | — | |
| Hydrochloric Acid SCHEMBL18262307 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737237-B2 | Controlled structure copolymer comprising an amphoteric or zwitterionic part | PHODIA CHIMIE (FR) | 2010-06-15 | — | — | US | claimed |
| US-20060217285-A1 | Controlled structure copolymer comprising an amphoteric or zwitterionic part | RHODIA CHIMIE (FR) | 2006-09-28 | — | — | US | claimed |