Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 2/20 | 0.47 |
| ▸ | F12 | P00748 | 1/20 | 0.47 |
| ▸ | NCF1 | P14598 | 1/20 | 0.47 |
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9352434 | 0.98 | CYP2A6 (0.50) | CYP2A6PLAUF12NCF1NOS3 | |
| SCHEMBL29277533 | 0.84 | CYP2A6 (0.55) | CYP2A6PLAUF12NCF1NOS3 | |
| SCHEMBL329993 | 0.82 | CYP2A6 (0.53) | CYP2A6PLAUF12NCF1NOS3 | |
| SCHEMBL10401348 | 0.82 | CYP2A6 (0.59) | CYP2A6PLAUF12NCF1NOS3 | |
| SCHEMBL1052021 | 0.81 | CYP2A6 (0.52) | CYP2A6PLAUF12NCF1NOS3 | |
| SCHEMBL169719 | 0.81 | PLAU (0.52) | CYP2A6PLAUF12NCF1NOS3 | |
| SCHEMBL29482553 | 0.81 | PLAU (0.52) | CYP2A6PLAUF12NCF1NOS3 | |
| SCHEMBL5610261 | 0.81 | CYP2A6 (0.52) | CYP2A6PLAUF12NCF1NOS3 | |
| SCHEMBL29797287 | 0.81 | CYP2A6 (0.52) | CYP2A6PLAUF12NCF1NOS3 | |
| Hydrochloric Acid SCHEMBL7319620 | 0.79 | CYP2A6 (0.50) | CYP2A6PLAUF12NCF1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117907492-B | High performance liquid chromatography method for simultaneously qualitatively and quantitatively detecting 5-isoquinoline sulfonic acid and six impurities thereof | 山东新华制药股份有限公司 | 2024-05-24 | — | — | CN | claimed |
| CN-117907492-A | High performance liquid chromatography method for simultaneously qualitatively and quantitatively detecting 5-isoquinoline sulfonic acid and six impurities thereof | 山东新华制药股份有限公司 | 2024-04-19 | — | — | CN | claimed |
| CN-113358759-B | Method for detecting related substances in fasudil hydrochloride starting material | 昆药集团股份有限公司 | 2022-11-18 | — | — | CN | claimed |
| CN-113358759-A | Method for detecting related substances in fasudil hydrochloride starting material | 昆药集团股份有限公司 | 2021-09-07 | — | — | CN | claimed |
| US-5216150-A | Muscle relaxant; enzyme inhibitor and platelet aggutination inhibitor | Hidaka, Hiroyoshi (JP) | 1993-06-01 | — | — | US | claimed |
| US-5081246-A | Isoquinolino sulfonamino derivatives | Hidaka, Hiroyoshi (JP) | 1992-01-14 | — | — | US | claimed |
| JP-61293914-A | — | — | None | — | — | JP | disclosed |
| CN-117907492-B | High performance liquid chromatography method for simultaneously qualitatively and quantitatively detecting 5-isoquinoline sulfonic acid and six impurities thereof | 山东新华制药股份有限公司 | 2024-05-24 | — | — | CN | disclosed |
| EP-4366733-A1 | TETRAHYDROPYRAZOLOPYRIDINE-ANALOG LIGANDS OF NLRX1 AND USES THEREOF | LANDOS BIOPHARMA, INC. (US) | 2024-05-15 | — | — | EP | disclosed |
| CN-117907492-A | High performance liquid chromatography method for simultaneously qualitatively and quantitatively detecting 5-isoquinoline sulfonic acid and six impurities thereof | 山东新华制药股份有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-117835980-A | Tetrahydropyrazolopyridine analog ligand of NLRX1 and application thereof | 朗多生物制药股份有限公司 | 2024-04-05 | — | — | CN | disclosed |
| EP-3927427-B1 | LANTHIONINE C-LIKE PROTEIN 2 LIGANDS, CELLS PREPARED THEREWITH, AND THERAPIES USING SAME | NIMMUNE BIOPHARMA INC (US) | 2024-02-07 | — | — | EP | disclosed |
| US-20230357744-A1 | ENGINEERED TRYPTOPHAN DECARBOXYLASES AND USES THEREOF FOR SYNTHESIZING TRYPTAMINE ANALOGS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2023-11-09 | — | — | US | disclosed |
| EP-0513691-A1 | Anti-ulcer agent | Hidaka, Hiroyoshi (JP) | 1992-11-19 | — | — | EP | disclosed |
| EP-0471841-A1 | SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1992-02-26 | — | — | EP | disclosed |
| US-5081246-A | Isoquinolino sulfonamino derivatives | Hidaka, Hiroyoshi (JP) | 1992-01-14 | — | — | US | disclosed |
| EP-0287696-B1 | ISOQUINOLINE DERIVATIVES | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1991-01-02 | — | — | EP | disclosed |
| EP-0350403-A1 | (Aza)naphthalenesultam derivatives, process for their preparation and drugs containing same | RHONE-POULENC SANTE (FR) | 1990-01-10 | — | — | EP | disclosed |
| EP-0287696-A1 | Isoquinoline derivatives | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1988-10-26 | — | — | EP | disclosed |
| JP-S61293914-A | ANTICANCER CONTAINING ISOQUINOLINE DERIVATIVE AS ACTIVE INGREDIENT | HIDAKA HIROYOSHI | 1986-12-24 | — | — | JP | disclosed |