Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.46 |
| ▸ | IDH2 | P48735 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.39 |
| ▸ | CCNK | O75909 | 3/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.39 |
| ▸ | CDK9 | P50750 | 3/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CCNH | P51946 | 1/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3300220 | 1.00 | CDK2 (0.46) | CDK2MAPKAPK2IDH2CHEK1IRAK4 | |
| SCHEMBL3299841 | 0.86 | CDK2 (0.46) | CDK2MAPKAPK2IDH2CHEK1IRAK4 | |
| SCHEMBL3303060 | 0.85 | IDH2 (0.48) | CDK2MAPKAPK2IDH2CHEK1CCNT1 | |
| SCHEMBL3299720 | 0.85 | IDH2 (0.48) | CDK2MAPKAPK2IDH2CHEK1CCNT1 | |
| SCHEMBL13392304 | 0.82 | IDH2 (0.45) | CDK2MAPKAPK2IDH2CCNT1CDK9 | |
| SCHEMBL3304385 | 0.82 | IDH2 (0.50) | CDK2MAPKAPK2IDH2CHEK1IRAK4 | |
| SCHEMBL3309511 | 0.82 | IDH2 (0.50) | CDK2MAPKAPK2IDH2CHEK1IRAK4 | |
| SCHEMBL3302493 | 0.82 | IDH2 (0.50) | CDK2MAPKAPK2IDH2CHEK1IRAK4 | |
| SCHEMBL3304480 | 0.81 | IDH2 (0.57) | CDK2MAPKAPK2IDH2CHEK1CTSS | |
| SCHEMBL3300452 | 0.81 | IDH2 (0.57) | CDK2MAPKAPK2IDH2CHEK1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-B1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2016-04-20 | — | — | EP | disclosed |
| US-20130005707-A1 | AMINOTRIAZOLOPYRIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | BAHMANYAR SOGOLE (US) | 2013-01-03 | — | — | US | disclosed |
| US-8299056-B2 | Aminotriazolopyridines, compositions thereof, and methods of treatment therewith | SIGNAL PHARMACEUTICALS, LLC (US) | 2012-10-30 | — | — | US | disclosed |
| US-20100093698-A1 | AMINOTRIAZOLOPYRIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130005707-A1 | AMINOTRIAZOLOPYRIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | MAP3K2, MAP3K1, MAP3K3 | CDK2 37/4885MAPKAPK2 23/4885IDH2 671/4885 |
| US-20100093698-A1 | AMINOTRIAZOLOPYRIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | MAP3K2, MAP3K1, MAP3K3 | CDK2 37/4885MAPKAPK2 23/4885IDH2 671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.