Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 17/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 17/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.31 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL419851 | 0.99 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1KDM4EGAAMAPT | |
| SCHEMBL3301787 | 0.98 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1KDM4EGAAMAPT | |
| SCHEMBL419020 | 0.92 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1KDM4EGAAMAPT | |
| SCHEMBL421098 | 0.88 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL421131 | 0.84 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1KDM4EGAAMAPT | |
| SCHEMBL1304724 | 0.83 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1KDM4EGAAMAPT | |
| SCHEMBL419879 | 0.82 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL421467 | 0.81 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1KDM4EGAAMAPT | |
| SCHEMBL421415 | 0.81 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1KDM4EGAAMAPT | |
| SCHEMBL421085 | 0.80 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188075-B2 | Triazole compounds that modulate HSP90 activity | SYNTA PHARMACEUTICALS CORP. (US) | 2012-05-29 | — | — | US | disclosed |
| US-20100093717-A1 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093717-A1 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AA1 2/4885HSP90AB1 1/4885KDM4E 3814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.