Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.63 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.63 |
| ▸ | ACHE | P22303 | 2/20 | 0.63 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.55 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.55 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.51 |
| ▸ | CRYAB | P02511 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CRYAA | P02489 | 1/20 | 0.46 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | HMGCR | P04035 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3303672 | 1.00 | TOP2A (0.63) | TOP2ATOP2BACHEPRKAG1PRKAA2 | |
| SCHEMBL1196806 | 0.87 | MAPK1 (0.50) | TOP2ATOP2BACHECRYABMAPK1 | |
| SCHEMBL1196805 | 0.87 | MAPK1 (0.50) | TOP2ATOP2BACHECRYABMAPK1 | |
| SCHEMBL13384621 | 0.84 | HMGCR (0.58) | TOP2ATOP2BACHEPRKAG1PRKAA2 | |
| SCHEMBL29934958 | 0.83 | MAPK1 (0.47) | TOP2ATOP2BACHECRYABMAPK1 | |
| SCHEMBL28676116 | 0.82 | MAPK1 (0.61) | TOP2ATOP2BACHECRYABMAPK1 | |
| SCHEMBL26642849 | 0.82 | MAPK1 (0.61) | TOP2ATOP2BACHECRYABMAPK1 | |
| SCHEMBL19728965 | 0.82 | MAPK1 (0.48) | TOP2ATOP2BACHECRYABMAPK1 | |
| SCHEMBL30651915 | 0.82 | MAPK1 (0.61) | TOP2ATOP2BACHECRYABMAPK1 | |
| SCHEMBL26642848 | 0.82 | MAPK1 (0.61) | TOP2ATOP2BACHECRYABMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100098788-A1 | Extracts of Curcuma and Methods of Use Thereof | HERBALSCIENCE GROUP, LLC | 2010-04-22 | — | — | US | disclosed |