Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 8/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 7/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3301804 | 0.84 | KLK7 (0.41) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL4438240 | 0.84 | KLK7 (0.41) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL3309464 | 0.75 | PPIA (0.41) | CA12CA1CA7CA14ATM | |
| SCHEMBL3305389 | 0.71 | BRD4 (0.30) | — | |
| SCHEMBL10387214 | 0.70 | KLK7 (0.61) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL10386697 | 0.70 | KLK7 (0.61) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL27527337 | 0.69 | KLK7 (0.57) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL20734805 | 0.69 | KLK7 (0.57) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL13205498 | 0.69 | KLK7 (0.57) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL247530 | 0.67 | KLK7 (0.54) | KLK7KLK5PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8592587-B2 | Transannular rearrangement of activated lactams | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2013-11-26 | — | — | US | disclosed |
| EP-2134681-B1 | TRANS-ANNULAR REARRANGEMENT OF ACTIVE LACTAMES | CENTRE NAT RECH SCIENT (FR) | 2012-05-16 | — | — | EP | disclosed |
| EP-2134681-B1 | TRANS-ANNULAR REARRANGEMENT OF ACTIVE LACTAMES | CENTRE NAT RECH SCIENT (FR) | 2012-05-16 | — | — | EP | disclosed |
| US-20100099874-A1 | TRANSANNULAR REARRANGEMENT OF ACTIVATED LACTAMS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS (FR) | 2010-04-22 | — | — | US | disclosed |
| WO-2008125421-A1 | TRANS-ANNULAR REARRANGEMENT OF ACTIVE LACTAMES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2008-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099874-A1 | TRANSANNULAR REARRANGEMENT OF ACTIVATED LACTAMS | C9, RPS4Y1, C5 | KLK7 4324/4885KLK5 4555/4885PRSS1 1843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.