Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 4/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.36 |
| ▸ | MDM4 | O15151 | 2/20 | 0.36 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3311066 | 0.92 | KDM4E (0.37) | PTGDR2MEN1KMT2AMDM2PTGES2 | |
| SCHEMBL3297264 | 0.87 | CYP3A4 (0.42) | PTGDR2MEN1KMT2AMDM2PTGES2 | |
| SCHEMBL3312494 | 0.85 | CYP3A4 (0.32) | PTGDR2KDM4E | |
| SCHEMBL15182599 | 0.84 | PTGES2 (0.41) | PTGDR2MEN1KMT2AMDM2PTGES2 | |
| SCHEMBL15186207 | 0.79 | CYP3A4 (0.42) | PTGES2PTGESKDM4E | |
| SCHEMBL15093467 | 0.79 | PPARG (0.43) | — | |
| SCHEMBL15102812 | 0.79 | PPARG (0.43) | — | |
| SCHEMBL15102803 | 0.79 | MAPK8 (0.39) | PTGDR2PTGES2PTGESMAPK8PSD | |
| SCHEMBL15093592 | 0.79 | MAPK8 (0.39) | PTGDR2PTGES2PTGESMAPK8PSD | |
| SCHEMBL252857 | 0.78 | PTGES2 (0.39) | PTGDR2MEN1KMT2AMDM2PTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003498-A1 | 2 -QUINOLINYL- ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | WO | disclosed |