Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 10/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 10/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 8/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | CCND1 | P24385 | 2/20 | 0.41 |
| ▸ | CCND2 | P30279 | 2/20 | 0.41 |
| ▸ | CCND3 | P30281 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | WEE1 | P30291 | 2/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3314387 | 0.90 | RIPK2 (0.51) | AURKARIPK2NOD2ACVR1ABL1 | |
| SCHEMBL3316162 | 0.90 | RIPK2 (0.53) | AURKARIPK2NOD2ACVR1ABL1 | |
| SCHEMBL3312781 | 0.88 | RIPK2 (0.53) | AURKARIPK2NOD2ACVR1ABL1 | |
| SCHEMBL3307388 | 0.87 | RIPK2 (0.50) | AURKARIPK2NOD2ACVR1ABL1 | |
| SCHEMBL3314321 | 0.86 | RIPK2 (0.52) | AURKARIPK2NOD2ACVR1ABL1 | |
| SCHEMBL3311064 | 0.86 | RIPK2 (0.53) | AURKARIPK2NOD2ACVR1ABL1 | |
| SCHEMBL3313138 | 0.86 | RIPK2 (0.59) | AURKARIPK2NOD2ACVR1ABL1 | |
| SCHEMBL14088400 | 0.86 | RIPK2 (0.51) | AURKARIPK2NOD2ACVR1ABL1 | |
| SCHEMBL3313035 | 0.85 | RIPK2 (0.55) | AURKARIPK2NOD2ACVR1ABL1 | |
| SCHEMBL3310082 | 0.85 | RIPK2 (0.59) | AURKARIPK2NOD2ACVR1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113445-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2010-05-06 | — | — | US | disclosed |
| US-20100113445-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2010-05-06 | — | — | US | disclosed |
| US-20100113445-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113445-A1 | Chemical Compounds | WEE1, WEE2, PRKDC | AURKA 251/4885RIPK2 1155/4885NOD2 3105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.