Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL242110 | 0.85 | PIK3CD (0.61) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL243232 | 0.82 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL241524 | 0.80 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL242377 | 0.76 | PIK3CD (0.63) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL243055 | 0.76 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL244881 | 0.74 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL2711307 | 0.73 | PIK3CD (0.70) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL2711501 | 0.73 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL2711703 | 0.72 | PIK3CD (0.77) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL14849163 | 0.72 | PIK3CD (0.68) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003264-A1 | NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS AS PIK3 -DELTA INHIBITORS | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |