Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 5/20 | 0.49 |
| ▸ | CCND1 | P24385 | 5/20 | 0.49 |
| ▸ | CCND2 | P30279 | 5/20 | 0.49 |
| ▸ | CCND3 | P30281 | 5/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 8/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 8/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 7/20 | 0.48 |
| ▸ | WEE1 | P30291 | 5/20 | 0.47 |
| ▸ | SRC | P12931 | 3/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3313445 | 0.93 | CDK4 (0.52) | AURKACDK4CCND1CCND2CCND3 | |
| SCHEMBL3311386 | 0.90 | CDK4 (0.49) | AURKACDK4CCND1CCND2CCND3 | |
| SCHEMBL3318060 | 0.90 | WEE1 (0.51) | AURKACDK4CCND1CCND2CCND3 | |
| SCHEMBL3311057 | 0.90 | CDK4 (0.51) | AURKACDK4CCND1CCND2CCND3 | |
| SCHEMBL3313711 | 0.90 | RIPK2 (0.56) | AURKACDK4CCND1CCND2CCND3 | |
| SCHEMBL3313176 | 0.90 | RIPK2 (0.60) | CDK4CCND1CCND2CCND3RIPK2 | |
| SCHEMBL3313138 | 0.89 | RIPK2 (0.59) | AURKACDK4CCND1CCND2CCND3 | |
| SCHEMBL3314387 | 0.88 | RIPK2 (0.51) | AURKACDK4CCND1CCND2CCND3 | |
| SCHEMBL3310109 | 0.88 | CDK4 (0.47) | AURKACDK4CCND1CCND2CCND3 | |
| SCHEMBL3313131 | 0.88 | RIPK2 (0.53) | AURKACDK4CCND1CCND2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113445-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2010-05-06 | — | — | US | disclosed |
| US-20100113445-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2010-05-06 | — | — | US | disclosed |
| US-20100113445-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2010-05-06 | — | — | US | disclosed |
| WO-2008115742-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113445-A1 | Chemical Compounds | WEE1, WEE2, PRKDC | AURKA 251/4885CDK4 91/4885CCND1 1238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.