Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 2/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.56 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.53 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3306992 | 0.99 | HRH3 (0.56) | ACKR3HRH3MLLT3MLLT1MEN1 | |
| SCHEMBL3310149 | 0.98 | HRH3 (0.58) | ACKR3HRH3MLLT3MLLT1MEN1 | |
| SCHEMBL3312877 | 0.86 | HRH3 (0.50) | HRH3 | |
| SCHEMBL3309141 | 0.85 | HRH3 (0.52) | ACKR3HRH3 | |
| SCHEMBL3310089 | 0.85 | HRH3 (0.50) | HRH3 | |
| SCHEMBL3310391 | 0.84 | KMT2A (0.60) | HRH3MEN1KMT2A | |
| SCHEMBL3307490 | 0.83 | HRH3 (0.48) | HRH3 | |
| SCHEMBL3305550 | 0.83 | HRH3 (0.50) | HRH3 | |
| SCHEMBL3305433 | 0.83 | HRH3 (0.55) | ACKR3HRH3 | |
| SCHEMBL3308234 | 0.83 | HRH3 (0.53) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113776-A1 | PYRAZOLE DERIVATIVE | TAISHO PHARMACEUTICAL CO.,LTD. (JP) | 2010-05-06 | — | — | US | claimed |
| US-20100113776-A1 | PYRAZOLE DERIVATIVE | TAISHO PHARMACEUTICAL CO.,LTD. (JP) | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113776-A1 | PYRAZOLE DERIVATIVE | HRH3, HRH4, HRH1 | ACKR3 503/4885HRH3 1/4885MLLT3 1776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.