SCHEMBL3316619

SCHEMBL3316619

O=C(/C=C/C1C=CCCC1)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.41
ALDH1A1 P00352 6/20 0.41
LMNA P02545 3/20 0.41
NPSR1 Q6W5P4 3/20 0.41
HPGD P15428 3/20 0.41
PLIN1 O60240 2/20 0.41
PLIN5 Q00G26 2/20 0.41
ABHD5 Q8WTS1 2/20 0.41
HTT P42858 1/20 0.41
RECQL P46063 2/20 0.41
MAOB P27338 2/20 0.41
BCHE P06276 1/20 0.41
TNFRSF1A P19438 1/20 0.41
ACHE P22303 1/20 0.41
CYP1B1 Q16678 1/20 0.41
NFE2L2 Q16236 1/20 0.40
NFKB1 P19838 3/20 0.38
NFKB2 Q00653 3/20 0.38
RELA Q04206 3/20 0.38
RAB9A P51151 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3316622 1.00 MAPT (0.41) MAPTALDH1A1LMNANPSR1HPGD
SCHEMBL976445 0.79 HTT (0.35) HTTNPC1SMN1; SMN2
SCHEMBL976442 0.79 HTT (0.35) HTTNPC1SMN1; SMN2
SCHEMBL28251467 0.74 MAPT (0.42) MAPTALDH1A1LMNANPSR1HPGD
SCHEMBL29561663 0.74 MAPT (0.42) MAPTALDH1A1LMNANPSR1HPGD
SCHEMBL30573 0.74 MAPT (0.42) MAPTALDH1A1LMNANPSR1HPGD
SCHEMBL2990482 0.74
SCHEMBL22272411 0.74 PADI4 (0.49) MAPTALDH1A1LMNANPSR1HPGD
SCHEMBL17064497 0.73 MAPT (0.52) MAPTALDH1A1LMNANPSR1HPGD
SCHEMBL17064498 0.73 MAPT (0.52) MAPTALDH1A1LMNANPSR1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100105766-A1 COMPOSITION FOR INHIBITION OR PREVENTION OF BONE DENSITY REDUCTION KIRIN BEER KABUSHIKI KAISHA 2010-04-29 US disclosed
EP-1618875-B1 COMPOSITION FOR INHIBITION OR PREVENTION OF BONE DENSITY LOWERING KIRIN BREWERY (JP) 2008-09-10 EP disclosed
US-20070059393-A1 Composition for inhibition or prevention of bone density KIRIN BEER KABUSHIKI KAISHA 2007-03-15 US disclosed
EP-1618875-A1 COMPOSITION FOR INHIBITION OR PREVENTION OF BONE DENSITY LOWERING AND REFRESHMENT THEREFOR KIRIN BEER KABUSHIKI KAISHA (JP) 2006-01-25 EP disclosed