Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.43 |
| ▸ | RORC | P51449 | 4/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4973467 | 0.94 | MEN1 (0.48) | MEN1KMT2AGPR119MMP13P2RX7 | |
| SCHEMBL26906342 | 0.91 | MEN1 (0.46) | MEN1KMT2AGPR119RORCMMP13 | |
| SCHEMBL23531641 | 0.86 | KMT2A (0.50) | MEN1KMT2AGPR119MMP13P2RX7 | |
| SCHEMBL4980907 | 0.86 | MEN1 (0.48) | MEN1KMT2AGPR119MMP13P2RX7 | |
| SCHEMBL19205366 | 0.82 | MEN1 (0.46) | MEN1KMT2AGPR119RORCMMP13 | |
| SCHEMBL27228991 | 0.81 | MEN1 (0.45) | MEN1KMT2AGPR119RORCMMP13 | |
| SCHEMBL27228997 | 0.80 | MEN1 (0.45) | MEN1KMT2AGPR119RORCMMP13 | |
| SCHEMBL24424679 | 0.80 | KMT2A (0.45) | MEN1KMT2AGPR119RORCMMP13 | |
| SCHEMBL29227450 | 0.80 | KMT2A (0.48) | MEN1KMT2AGPR119MMP13 | |
| SCHEMBL16520138 | 0.80 | KMT2A (0.50) | MEN1KMT2AGPR119MMP13P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367696-B2 | Aza-bridged-ring compound | ASTELLAS PHARMA INC. (JP) | 2013-02-05 | — | — | US | disclosed |
| US-8367696-B2 | Aza-bridged-ring compound | ASTELLAS PHARMA INC. (JP) | 2013-02-05 | — | — | US | disclosed |
| US-8367696-B2 | Aza-bridged-ring compound | ASTELLAS PHARMA INC. (JP) | 2013-02-05 | — | — | US | disclosed |
| US-20100105658-A1 | AZA-BRIDGED-RING COMPOUND | ASTELLAS PHARMA INC. (JP) | 2010-04-29 | — | — | US | disclosed |
| US-20100105658-A1 | AZA-BRIDGED-RING COMPOUND | ASTELLAS PHARMA INC. (JP) | 2010-04-29 | — | — | US | disclosed |
| US-20100105658-A1 | AZA-BRIDGED-RING COMPOUND | ASTELLAS PHARMA INC. (JP) | 2010-04-29 | — | — | US | disclosed |
| EP-2119716-A1 | AZA-BRIDGED-RING COMPOUND | Astellas Pharma Inc. (JP) | 2009-11-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105658-A1 | AZA-BRIDGED-RING COMPOUND | CHRM3, CHRM1, CHRM2 | MEN1 4138/4885KMT2A 496/4885GPR119 708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.