Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 15/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 5/20 | 0.60 |
| ▸ | CASP1 | P29466 | 4/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | F2 | P00734 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | CASP7 | P55210 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3323937 | 0.87 | KDM4E (0.65) | KDM4EALDH1A1HSD17B10MAPTMEN1 | |
| SCHEMBL10704884 | 0.83 | KDM4E (0.62) | KDM4EALDH1A1HSD17B10MAPTKMT2A | |
| SCHEMBL3323526 | 0.80 | KDM4E (0.65) | KDM4EALDH1A1HSD17B10MAPTMEN1 | |
| SCHEMBL11691221 | 0.78 | KDM4E (0.56) | KDM4EALDH1A1HSD17B10MAPTMEN1 | |
| SCHEMBL3324497 | 0.77 | KDM4E (0.63) | KDM4EALDH1A1HSD17B10MAPTMEN1 | |
| SCHEMBL3329970 | 0.76 | KDM4E (0.59) | KDM4EALDH1A1HSD17B10MAPTMEN1 | |
| SCHEMBL3325394 | 0.76 | KDM4E (0.51) | KDM4EALDH1A1HSD17B10MAPTMEN1 | |
| SCHEMBL29693490 | 0.75 | SMN1; SMN2 (0.57) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL11687992 | 0.75 | TDP1 (0.53) | KDM4EALDH1A1HSD17B10MAPTKMT2A | |
| SCHEMBL3328880 | 0.73 | KDM4E (0.65) | KDM4EALDH1A1HSD17B10HPGDCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | APP, MAPT, PSEN1 | KDM4E 4115/4885ALDH1A1 2615/4885HSD17B10 1530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.