Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | NRAS | P01111 | 1/20 | 0.45 |
| ▸ | PTK6 | Q13882 | 4/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3848551 | 0.99 | NPC1 (0.47) | NPC1RAB9APOLBFLT3MAPK1 | |
| SCHEMBL16241777 | 0.84 | ROCK1 (0.45) | FLT3NRASPTK6RPS6KB1ROCK1 | |
| Hydrochloric Acid SCHEMBL3849761 | 0.83 | ROCK1 (0.44) | FLT3NRASPTK6RPS6KB1ROCK1 | |
| SCHEMBL3323424 | 0.80 | NPC1 (0.43) | NPC1RAB9APOLBKMT2AFGFR3 | |
| SCHEMBL3322932 | 0.80 | KDM4E (0.46) | NPC1RAB9APOLBFLT3NRAS | |
| Hydrochloric Acid SCHEMBL3846069 | 0.79 | KDM4E (0.46) | NPC1RAB9APOLBFLT3NRAS | |
| SCHEMBL4712318 | 0.78 | KDM4E (0.41) | POLBFLT3MAPK1NRASRPS6KB1 | |
| Hydrochloric Acid SCHEMBL3849122 | 0.78 | KDM4E (0.40) | POLBFLT3MAPK1NRASPTK6 | |
| Hydrochloric Acid SCHEMBL3846953 | 0.76 | KIT (0.39) | NPC1RAB9AFLT3NRASPTK6 | |
| SCHEMBL3323428 | 0.75 | NPC1 (0.38) | NPC1RAB9APOLBFLT3NRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120761-A1 | Bicyclic Heterocyclic Compounds as FGFR Inhibitors | ASTEX THERAPEUTICS LIMITED (GB) | 2010-05-13 | — | — | US | claimed |
| US-8895745-B2 | Bicyclic heterocyclic compounds as FGFR inhibitors | ASTEX THERAPEUTICS LIMITED (GB) | 2014-11-25 | — | — | US | disclosed |
| US-20100120761-A1 | Bicyclic Heterocyclic Compounds as FGFR Inhibitors | ASTEX THERAPEUTICS LIMITED (GB) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120761-A1 | Bicyclic Heterocyclic Compounds as FGFR Inhibitors | FGFR3, FGFR1, FGFR2 | NPC1 2126/4885RAB9A 2987/4885POLB 3202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.