Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 17/20 | 0.54 |
| ▸ | ABL1 | P00519 | 9/20 | 0.54 |
| ▸ | INSR | P06213 | 9/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.54 |
| ▸ | CDK2 | P24941 | 9/20 | 0.54 |
| ▸ | PLK1 | P53350 | 9/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.54 |
| ▸ | GAK | O14976 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5417331 | 0.84 | EGFR (0.63) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL3320475 | 0.82 | EGFR (0.72) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL4720051 | 0.79 | EGFR (0.60) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL8138833 | 0.78 | EGFR (0.64) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL3321388 | 0.76 | EGFR (0.59) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL3326173 | 0.76 | EGFR (0.68) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL3322768 | 0.76 | EGFR (0.63) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL4717905 | 0.75 | EGFR (0.70) | EGFRERBB2GAKERBB4 | |
| SCHEMBL3323096 | 0.75 | EGFR (0.59) | EGFRERBB2ABL1INSRPDGFRB | |
| SCHEMBL4009625 | 0.75 | EGFR (0.72) | EGFRERBB2ABL1INSRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8513262-B2 | Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2013-08-20 | — | — | US | disclosed |
| US-20100120804-A1 | Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120804-A1 | Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors | ABL1, ERBB2, CDK2 | EGFR 69/4885ERBB2 2/4885ABL1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.