Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.78 |
| ▸ | TSHR | P16473 | 2/20 | 0.78 |
| ▸ | GAA | P10253 | 5/20 | 0.69 |
| ▸ | HPGD | P15428 | 3/20 | 0.69 |
| ▸ | GLA | P06280 | 2/20 | 0.69 |
| ▸ | CASP1 | P29466 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CASP7 | P55210 | 2/20 | 0.55 |
| ▸ | NOTCH1 | P46531 | 2/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.55 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.55 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.55 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.55 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16854541 | 0.92 | KDM4E (0.81) | KDM4EALDH1A1TSHRGAAHPGD | |
| SCHEMBL12135876 | 0.88 | KDM4E (0.70) | KDM4EALDH1A1TSHRGAAHPGD | |
| SCHEMBL19676418 | 0.87 | KDM4E (0.74) | KDM4EALDH1A1TSHRGAAHPGD | |
| SCHEMBL3326234 | 0.84 | KDM4E (0.79) | KDM4EALDH1A1TSHRGAAHPGD | |
| SCHEMBL3325137 | 0.84 | NOTCH1 (0.76) | KDM4EALDH1A1TSHRGAAHPGD | |
| SCHEMBL3326956 | 0.82 | KDM4E (0.70) | KDM4EALDH1A1TSHRGAAHPGD | |
| SCHEMBL7979577 | 0.82 | KDM4E (0.62) | KDM4EALDH1A1TSHRGAAHPGD | |
| SCHEMBL3325186 | 0.82 | KDM4E (0.67) | KDM4EALDH1A1TSHRGAAHPGD | |
| SCHEMBL3326465 | 0.81 | KDM4E (0.69) | KDM4EALDH1A1TSHRGAAHPGD | |
| SCHEMBL3329810 | 0.80 | KDM4E (0.65) | KDM4EALDH1A1TSHRGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | APP, MAPT, PSEN1 | KDM4E 4115/4885ALDH1A1 2615/4885TSHR 4847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.