Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.38 |
| ▸ | PDE2A | O00408 | 4/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.38 |
| ▸ | RAC1 | P63000 | 2/20 | 0.36 |
| ▸ | FABP3 | P05413 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 2/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3334028 | 0.89 | SMN1; SMN2 (0.45) | LMNAMAPK1HTTSMN1; SMN2ORAI1 | |
| SCHEMBL3331310 | 0.83 | RAC1 (0.39) | SMN1; SMN2PDE2APDE10ARAC1MEN1 | |
| SCHEMBL3338724 | 0.83 | RAC1 (0.39) | SMN1; SMN2PDE10ARAC1MEN1KMT2A | |
| SCHEMBL13165374 | 0.72 | NPC1 (0.44) | LMNAMAPK1HTTSMN1; SMN2PDE2A | |
| SCHEMBL12394014 | 0.71 | MEN1 (0.49) | LMNAMAPK1PDE2APDE10AMEN1 | |
| SCHEMBL3333863 | 0.71 | IKBKB (0.38) | SMN1; SMN2RAC1KMT2AMAPK10IKBKB | |
| SCHEMBL3575097 | 0.71 | NPC1 (0.39) | ORAI1PDE2APDE10AMEN1KMT2A | |
| SCHEMBL3331683 | 0.71 | CYP1A2 (0.43) | SMN1; SMN2RAC1IKBKBCYP2C9 | |
| SCHEMBL3311845 | 0.70 | NPC1 (0.42) | LMNAMAPK1HTTSMN1; SMN2PDE2A | |
| SCHEMBL3310669 | 0.70 | KDM4E (0.37) | SMN1; SMN2ORAI1PDE2APDE10AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144674-A1 | PYRIDAZINE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-06-10 | — | — | US | claimed |
| EP-2077997-A1 | PYRIDAZINE DERIVATIVES | Syngeta Participations AG (CH) | 2009-07-15 | — | — | EP | claimed |
| WO-2008049585-A1 | PYRIDAZINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-05-02 | — | — | WO | claimed |
| US-20100144674-A1 | PYRIDAZINE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| EP-2077997-A1 | PYRIDAZINE DERIVATIVES | Syngeta Participations AG (CH) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008049585-A1 | PYRIDAZINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144674-A1 | PYRIDAZINE DERIVATIVES | C3AR1, C1S, CBR3 | LMNA 3400/4885MAPK1 1828/4885HTT 1885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.