Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 1/20 | 0.65 |
| ▸ | CDK2 | P24941 | 1/20 | 0.65 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.65 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.65 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.65 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.65 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.65 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.65 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.65 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 15/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 8/20 | 0.60 |
| ▸ | HPGD | P15428 | 6/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.60 |
| ▸ | CASP1 | P29466 | 5/20 | 0.60 |
| ▸ | CASP7 | P55210 | 4/20 | 0.60 |
| ▸ | GLA | P06280 | 3/20 | 0.60 |
| ▸ | USP2 | O75604 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3322699 | 0.91 | KDM4E (0.67) | CCNA2CDK2NOTCH1PSEN1PSEN2 | |
| SCHEMBL3323562 | 0.91 | KDM4E (0.68) | NOTCH1KDM4EALDH1A1TSHRGAA | |
| SCHEMBL3323101 | 0.90 | KDM4E (0.67) | KDM4EALDH1A1TSHRGAAHPGD | |
| SCHEMBL3329810 | 0.89 | KDM4E (0.65) | KDM4EALDH1A1TSHRGAAHPGD | |
| SCHEMBL15536537 | 0.87 | KDM4E (0.74) | CCNA2CDK2NOTCH1PSEN1PSEN2 | |
| SCHEMBL3325303 | 0.87 | KDM4E (0.82) | KDM4EALDH1A1TSHRGAAHPGD | |
| SCHEMBL3324833 | 0.87 | KDM4E (0.68) | CCNA2CDK2NOTCH1PSEN1PSEN2 | |
| SCHEMBL3324829 | 0.87 | CCNA2 (0.66) | CCNA2CDK2NOTCH1PSEN1PSEN2 | |
| SCHEMBL3322753 | 0.86 | KDM4E (0.49) | CCNA2CDK2NOTCH1PSEN1PSEN2 | |
| SCHEMBL3323073 | 0.86 | KDM4E (0.62) | KDM4EALDH1A1TSHRGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | APP, MAPT, PSEN1 | CCNA2 2159/4885CDK2 1983/4885NOTCH1 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.