Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 18/20 | 0.63 |
| ▸ | PDE2A | O00408 | 17/20 | 0.63 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3321720 | 0.79 | PDE2A (0.83) | PDE10APDE2A | |
| SCHEMBL3325670 | 0.78 | PDE2A (0.82) | PDE10APDE2A | |
| SCHEMBL3328280 | 0.78 | PDE2A (1.00) | PDE10APDE2A | |
| SCHEMBL3321196 | 0.76 | PDE10A (0.75) | PDE10APDE2A | |
| SCHEMBL12503095 | 0.73 | PDE2A (1.00) | PDE10APDE2A | |
| SCHEMBL12502536 | 0.73 | PDE2A (1.00) | PDE10APDE2AESR2 | |
| SCHEMBL3325943 | 0.72 | PDE2A (0.65) | PDE10APDE2AESR2 | |
| SCHEMBL3325586 | 0.72 | PDE2A (0.67) | PDE10APDE2A | |
| SCHEMBL3330230 | 0.71 | PDE2A (0.82) | PDE10APDE2A | |
| SCHEMBL3321674 | 0.71 | PDE2A (0.86) | PDE10APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120763-A1 | IMIDAZO[5,1-C][1,2,4]BENZOTRIAZINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES | WYETH (US) | 2010-05-13 | — | — | US | claimed |
| US-20100120763-A1 | IMIDAZO[5,1-C][1,2,4]BENZOTRIAZINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES | WYETH (US) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120763-A1 | IMIDAZO[5,1-C][1,2,4]BENZOTRIAZINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES | PDE2A, PDE5A, PDE3A | PDE10A 13/4885PDE2A 1/4885ESR2 3561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.