Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 6/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3333495 | 1.00 | HDAC3 (0.39) | HDAC3HDAC1HDAC2HDAC6AKT1 | |
| SCHEMBL3331914 | 0.86 | MME (0.42) | HDAC3HDAC1HDAC6MEN1KMT2A | |
| SCHEMBL3329760 | 0.83 | NTRK1 (0.37) | HDAC6AKT1MEN1CYP1A2CYP2D6 | |
| SCHEMBL3329764 | 0.83 | NTRK1 (0.37) | HDAC6AKT1MEN1CYP1A2CYP2D6 | |
| SCHEMBL1530020 | 0.81 | AKT1 (0.40) | HDAC3HDAC1HDAC2HDAC6AKT1 | |
| SCHEMBL1530022 | 0.81 | AKT1 (0.40) | HDAC3HDAC1HDAC2HDAC6AKT1 | |
| SCHEMBL1529843 | 0.80 | EPHX2 (0.38) | HDAC6AKT1AKT2AKT3PPARG | |
| SCHEMBL1529841 | 0.80 | EPHX2 (0.38) | HDAC6AKT1AKT2AKT3PPARG | |
| SCHEMBL13300019 | 0.79 | SCN9A (0.42) | HDAC3HDAC1HDAC2HDAC6AKT1 | |
| SCHEMBL1529426 | 0.79 | AKT1 (0.46) | AKT1AKT2AKT3PPARGEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338434-B2 | Inhibitors of Akt activity | GLAXOSMITHKLINE LLC (US) | 2012-12-25 | — | — | US | disclosed |
| US-20100137338-A1 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137338-A1 | INHIBITORS OF Akt ACTIVITY | PI4KB, AKT3, AKT2 | HDAC3 859/4885HDAC1 433/4885HDAC2 628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.