Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 8/20 | 0.54 |
| ▸ | AKR1B10 | O60218 | 7/20 | 0.54 |
| ▸ | AKR1A1 | P14550 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.45 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2847794 | 0.87 | KDM4E (0.49) | AKR1B1KDM4EHPGDHTTNPSR1 | |
| SCHEMBL3331245 | 0.84 | KDM4E (0.46) | AKR1B1AKR1B10AKR1A1KDM4EHPGD | |
| SCHEMBL2844856 | 0.84 | AKR1B1 (0.56) | AKR1B1AKR1B10AKR1A1KDM4EHPGD | |
| SCHEMBL2819336 | 0.84 | KDM4E (0.70) | AKR1B1AKR1B10AKR1A1KDM4EHPGD | |
| SCHEMBL2822185 | 0.83 | KDM4E (0.57) | AKR1B1AKR1B10AKR1A1KDM4EHPGD | |
| SCHEMBL2854047 | 0.81 | TDP1 (0.44) | AKR1B1AKR1B10AKR1A1KDM4EHPGD | |
| SCHEMBL2820567 | 0.81 | KDM4E (0.44) | AKR1B1AKR1B10AKR1A1KDM4EHPGD | |
| SCHEMBL2821223 | 0.78 | AKR1B1 (0.57) | AKR1B1AKR1B10AKR1A1KDM4EHPGD | |
| SCHEMBL2824992 | 0.77 | KDM4E (0.49) | AKR1B1AKR1B10AKR1A1KDM4EHPGD | |
| SCHEMBL2821013 | 0.75 | AKR1B1 (0.59) | AKR1B1AKR1B10AKR1A1BAZ2BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198447-B2 | Fused tricyclic compound having aldose reductase inhibitory activity | NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA (JP) | 2012-06-12 | — | — | US | disclosed |
| US-8198447-B2 | Fused tricyclic compound having aldose reductase inhibitory activity | NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA (JP) | 2012-06-12 | — | — | US | disclosed |
| US-8198447-B2 | Fused tricyclic compound having aldose reductase inhibitory activity | NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA (JP) | 2012-06-12 | — | — | US | disclosed |
| US-20100145052-A1 | FUSED TRICYCLIC COMPOUND HAVING ALDOSE REDUCTASE INHIBITORY ACTIVITY | NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA (JP) | 2010-06-10 | — | — | US | disclosed |
| US-20100145052-A1 | FUSED TRICYCLIC COMPOUND HAVING ALDOSE REDUCTASE INHIBITORY ACTIVITY | NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA (JP) | 2010-06-10 | — | — | US | disclosed |
| US-20100145052-A1 | FUSED TRICYCLIC COMPOUND HAVING ALDOSE REDUCTASE INHIBITORY ACTIVITY | NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA (JP) | 2010-06-10 | — | — | US | disclosed |
| EP-2179999-A1 | FUSED TRICYCLIC COMPOUND HAVING ALDOSE REDUCTASE INHIBITORY ACTIVITY | National University Corporation University Of Toyama (JP) | 2010-04-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100145052-A1 | FUSED TRICYCLIC COMPOUND HAVING ALDOSE REDUCTASE INHIBITORY ACTIVITY | AKR1C4, AKR1C2, AKR1C3 | AKR1B1 4/4885AKR1B10 10/4885AKR1A1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.