Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.65 |
| ▸ | CDC7 | O00311 | 8/20 | 0.65 |
| ▸ | GSK3B | P49841 | 2/20 | 0.65 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.65 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.65 |
| ▸ | CLK1 | P49759 | 1/20 | 0.65 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.65 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.65 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11915777 | 0.88 | CDC7 (0.79) | PIM1CDC7GSK3BCSNK2A1CSNK2A2 | |
| SCHEMBL12514208 | 0.87 | CDC7 (0.66) | PIM1CDC7GSK3BCSNK2A1CSNK2A2 | |
| SCHEMBL383935 | 0.86 | PIM1 (0.65) | PIM1CDC7GSK3BCSNK2A1CSNK2A2 | |
| SCHEMBL14547357 | 0.84 | PIM1 (0.80) | PIM1CDC7GSK3BCSNK2A1CSNK2A2 | |
| SCHEMBL3329659 | 0.81 | PIM1 (0.56) | PIM1CDC7GSK3BCSNK2A1CSNK2A2 | |
| SCHEMBL3331554 | 0.80 | PDE10A (0.50) | PIM1CDC7GSK3BCSNK2A1CSNK2A2 | |
| SCHEMBL386108 | 0.80 | CDC7 (0.82) | PIM1CDC7GSK3BCSNK2A1CSNK2A2 | |
| SCHEMBL385819 | 0.80 | CDC7 (0.82) | PIM1CDC7GSK3BCSNK2A1CSNK2A2 | |
| SCHEMBL383517 | 0.80 | PIM1 (0.77) | PIM1CDC7GSK3BCSNK2A1CSNK2A2 | |
| SCHEMBL3333095 | 0.79 | PIM1 (0.54) | PIM1CDC7GSK3BCSNK2A1CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8242129-B2 | 6-phenylpyrimidinones as PIM modulators | EXELIXIS, INC. (US) | 2012-08-14 | — | — | US | disclosed |
| US-20100135954-A1 | 6-Phenylpyrimidinones as PIM Modulators | EXELIXIS, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| EP-2074103-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008133955-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | EXELIXIS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100135954-A1 | 6-Phenylpyrimidinones as PIM Modulators | PIM1, PIM2, PIM3 | PIM1 1/4885CDC7 3813/4885GSK3B 907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.