Histidine

Histidine

SCHEMBL3335322

C[C@H](N)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 3/20 0.43
CYP3A4 P08684 2/20 0.43
CYP1A2 P05177 1/20 0.42
GRIA2 P42262 6/20 0.40
GRIA1 P42261 5/20 0.40
GRIA3 P42263 5/20 0.40
GRIA4 P48058 5/20 0.40
PKM P14618 2/20 0.39
ALPI P09923 1/20 0.39
PTGS1 P23219 1/20 0.39
XIAP P98170 1/20 0.39
GRIK1 P39086 2/20 0.36
GRIK2 Q13002 2/20 0.36
GRIK3 Q13003 2/20 0.36
GRIK4 Q16099 2/20 0.36
GRIK5 Q16478 2/20 0.36
HSD17B10 Q99714 2/20 0.36
KDM4E B2RXH2 2/20 0.36
MEN1 O00255 2/20 0.36
LMNA P02545 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL3457996 1.00 SLC7A5 (0.43) SLC7A5CYP3A4CYP1A2GRIA2GRIA1
Histidine SCHEMBL4610837 1.00 SLC7A5 (0.43) SLC7A5CYP3A4CYP1A2GRIA2GRIA1
Histidine SCHEMBL7521151 0.94 SLC7A5 (0.39) SLC7A5CYP3A4CYP1A2GRIA2GRIA1
Histidine SCHEMBL20678156 0.94 SLC7A5 (0.39) SLC7A5CYP3A4CYP1A2GRIA2GRIA1
Histidine SCHEMBL27615468 0.94 SLC7A5 (0.41) SLC7A5CYP3A4CYP1A2GRIA2GRIA1
Histidine SCHEMBL28093403 0.94 SLC7A5 (0.45) SLC7A5CYP3A4CYP1A2GRIA2GRIA1
Histidine SCHEMBL3050310 0.94 SLC7A5 (0.49) SLC7A5CYP3A4CYP1A2GRIA2GRIA1
Histidine SCHEMBL3050307 0.94 SLC7A5 (0.49) SLC7A5CYP3A4CYP1A2GRIA2GRIA1
Histidine SCHEMBL163443 0.94 SLC7A5 (0.47) SLC7A5CYP3A4CYP1A2GRIA2GRIA1
Histidine SCHEMBL8080341 0.94 SLC7A5 (0.47) SLC7A5CYP3A4CYP1A2GRIA2GRIA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0368920-A1 LECTINES FIXING BETA-D-GALACTOSIDE. IDEON CORP (US) 1990-05-23 EP claimed
WO-1989000581-A1 LECTINES FIXING BETA-D-GALACTOSIDE IDEON CORPORATION (US) 1989-01-26 WO claimed
CN-115746110-A Mutant of transcriptional regulatory factor LysG and application thereof 中国科学院天津工业生物技术研究所 2023-03-07 CN disclosed
CN-115746111-A Mutant of transcription regulatory factor LysG and application thereof 中国科学院天津工业生物技术研究所 2023-03-07 CN disclosed
CN-113795588-A Methods for scar-free introduction of targeted modifications in targeting vectors 瑞泽恩制药公司 2021-12-14 CN disclosed
CN-111743798-A Multi-effect anti-aging skin care product and preparation method thereof 合肥卡迪尔生物科技有限公司 2020-10-09 CN disclosed
CN-111228509-A Bispecific anti-hapten/anti-blood brain barrier receptor antibodies, complexes thereof and their use as blood brain barrier shuttles 豪夫迈·罗氏有限公司 2020-06-05 CN disclosed
CN-105899540-B Bispecific anti-hapten/anti-blood-brain barrier receptor antibodies, complexes thereof and their use as blood-brain barrier shuttles 豪夫迈·罗氏有限公司 2020-02-07 CN disclosed
CN-105985425-B polyethylene glycol modified exendin analogue and preparation method and application thereof 浙江海昶生物医药技术有限公司 2019-12-17 CN disclosed
EP-3314264-A1 MEANS AND METHODS FOR DIAGNOSING PANCREATIC CANCER IN A SUBJECT BASED ON A BIOMARKER PANEL Metanomics Health GmbH (DE) 2018-05-02 EP disclosed
WO-2016207391-A1 MEANS AND METHODS FOR DIAGNOSING PANCREATIC CANCER IN A SUBJECT BASED ON A BIOMARKER PANEL METANOMICS HEALTH GMBH (DE) 2016-12-29 WO disclosed
WO-2002032450-A2 VACCINES GLAXOSMITHKLINE BIOLOGICALS S.A. (BE) 2002-04-25 WO disclosed
EP-1194571-A1 PROSTASE VACCINE SMITHKLINE BEECHAM BIOLOGICALS s.a. (BE) 2002-04-10 EP disclosed
WO-2002000867-A1 PROSTASE PROTEIN VACCINE COMPRISING DERIVATISED THIOL RESIDUES AND METHODS FOR PRODUCING SAID ANTIGEN GLAXOSMITHKLINE BIOLOGICALS S.A. (BE) 2002-01-03 WO disclosed
WO-2002000708-A2 MUTANTS OF PROSTASE SMITHKLINE BEECHAM BIOLOGICALS S.A. (BE) 2002-01-03 WO disclosed
WO-2001004143-A2 PROSTASE VACCINE SMITHKLINE BEECHAM BIOLOGICALS S.A. (BE) 2001-01-18 WO disclosed
EP-0772669-A1 SALINE SOLUTION FOR TREATING CONTACT LENSES ALCON LABORATORIES, INC. (US) 1997-05-14 EP disclosed
WO-1996003484-A1 SALINE SOLUTION FOR TREATING CONTACT LENSES ALCON LABORATORIES, INC. (US) 1996-02-08 WO disclosed
EP-0368920-A1 LECTINES FIXING BETA-D-GALACTOSIDE. IDEON CORP (US) 1990-05-23 EP disclosed
WO-1989000581-A1 LECTINES FIXING BETA-D-GALACTOSIDE IDEON CORPORATION (US) 1989-01-26 WO disclosed