Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 4/20 | 0.47 |
| ▸ | PRKAG2 | Q9UGJ0 | 4/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13302169 | 0.85 | SMN1; SMN2 (0.44) | KDM4ESMN1; SMN2ALDH1A1HPGDNPC1 | |
| SCHEMBL3332983 | 0.84 | GFER (0.42) | SMN1; SMN2CDC25BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL15780703 | 0.78 | KDM4E (0.64) | KDM4ESMN1; SMN2ALDH1A1HPGDNPC1 | |
| SCHEMBL2456084 | 0.77 | GSTP1 (0.55) | KDM4ESMN1; SMN2ALDH1A1HPGDNPC1 | |
| SCHEMBL13828205 | 0.76 | KDM4E (0.58) | KDM4ESMN1; SMN2ALDH1A1HPGDNPC1 | |
| SCHEMBL2879060 | 0.75 | KDM4E (0.57) | KDM4ESMN1; SMN2ALDH1A1HPGDNPC1 | |
| SCHEMBL2510203 | 0.73 | CDC25B (0.64) | KDM4ESMN1; SMN2ALDH1A1HPGDNPC1 | |
| SCHEMBL31613816 | 0.73 | CDC25B (0.64) | KDM4ESMN1; SMN2ALDH1A1HPGDNPC1 | |
| SCHEMBL12019936 | 0.73 | GSTP1 (0.65) | KDM4ESMN1; SMN2ALDH1A1HPGDNPC1 | |
| SCHEMBL11871562 | 0.72 | CSNK2A2 (0.41) | KDM4ESMN1; SMN2NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362066-B2 | Compounds and methods for treating protein folding disorders | TREVENTIS CORPORATION (US) | 2013-01-29 | — | — | US | disclosed |
| US-8362066-B2 | Compounds and methods for treating protein folding disorders | TREVENTIS CORPORATION (US) | 2013-01-29 | — | — | US | disclosed |
| US-8362066-B2 | Compounds and methods for treating protein folding disorders | TREVENTIS CORPORATION (US) | 2013-01-29 | — | — | US | disclosed |
| US-20100144821-A1 | COMPOUNDS AND METHODS FOR TREATING PROTEIN FOLDING DISORDERS | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2010-06-10 | — | — | US | disclosed |
| US-20100144821-A1 | COMPOUNDS AND METHODS FOR TREATING PROTEIN FOLDING DISORDERS | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2010-06-10 | — | — | US | disclosed |
| US-20100144821-A1 | COMPOUNDS AND METHODS FOR TREATING PROTEIN FOLDING DISORDERS | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2010-06-10 | — | — | US | disclosed |
| WO-2008058402-A1 | COMPOUNDS AND METHODS FOR TREATING PROTEIN FOLDING DISORDERS | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2008-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144821-A1 | COMPOUNDS AND METHODS FOR TREATING PROTEIN FOLDING DISORDERS | SNCA, MAPT, APP | KDM4E 1608/4885SMN1; SMN2 141/4885ALDH1A1 3687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.