⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2490137 | 0.83 | — | — | |
| SCHEMBL2489310 | 0.75 | — | — | |
| SCHEMBL28894473 | 0.73 | — | — | |
| SCHEMBL2488031 | 0.71 | — | — | |
| SCHEMBL2485139 | 0.71 | — | — | |
| SCHEMBL18757211 | 0.69 | — | — | |
| SCHEMBL2489273 | 0.68 | — | — | |
| SCHEMBL3892575 | 0.65 | AR (0.30) | — | |
| SCHEMBL26874463 | 0.65 | — | — | |
| SCHEMBL25287 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140303372-A1 | SULFONYLPYRAZOLE AND SULFONYLPYRAZOLINE CARBOXAMIDINE DERIVATIVES AS 5-HT6 ANTAGONISTS | ABBVIE BHAMAS LTD. (BS) | 2014-10-09 | — | — | US | disclosed |
| US-8722887-B2 | Sulfonylpyrazole and sulfonylpyrazoline carboxamidine derivatives as 5-HT6 antagonists | Abbvie Bahamas, Ltd. (BS) | 2014-05-13 | — | — | US | disclosed |
| EP-2069310-B1 | SULFONYLPYRAZOLINE-1-CARBOXAMIDINE DERIVATIVES AS 5-HT6 ANTAGONISTS | ABBOTT HEALTHCARE PRODUCTS BV (NL) | 2011-12-14 | — | — | EP | disclosed |
| US-20100145042-A1 | SULFONYLPYRAZOLE AND SULFONYLPYRAZOLINE CARBOXAMIDINE DERIVATIVES AS 5-HT6 ANTAGONISTS | SOLVAY PHARMACEUTICALS B.V. | 2010-06-10 | — | — | US | disclosed |
| US-7728018-B2 | for treating disease or condition chosen from Parkinson's disease, Huntington's chorea, schizophrenia, anxiety, depression, manic depression, psychoses, epilepsy, obsessive compulsive disorders, mood disorders, migraine, Alzheimer's disease, age related cognitive decline, sleep, eating disorders | SOLVAY PHARMACEUTICALS B.V. (NL) | 2010-06-01 | — | — | US | disclosed |
| EP-2069310-A2 | SULFONYLPYRAZOLINE CARBOXAMIDINE DERIVATIVES AS 5-HT6 ANTAGONISTS | Solvay Pharmaceuticals B.V. (NL) | 2009-06-17 | — | — | EP | disclosed |
| US-20080311179-A1 | for treating disease or condition chosen from Parkinson's disease, Huntington's chorea, schizophrenia, anxiety, depression, manic depression, psychoses, epilepsy, obsessive compulsive disorders, mood disorders, migraine, Alzheimer's disease, age related cognitive decline, sleep, eating disorders | ABBOTT HOSPITALS LIMITED (BS) | 2008-12-18 | — | — | US | disclosed |
| WO-2008034863-A2 | SULFONYLPYRAZOLINE CARBOXAMIDINE DERIVATIVES AS 5-HT6 ANTAGONISTS | SOLVAY PHARMACEUTICALS B.V. (NL) | 2008-03-27 | — | — | WO | disclosed |