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Cosyntropin

Cosyntropin

SCHEMBL33367

CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C)C(C)C

nearest known ligand 0.81

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

MC2R

The experimentally established mechanism targets of Cosyntropin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ MC4R P32245 3/20 0.81
▸ MC5R P33032 2/20 0.81
▸ MC3R P41968 2/20 0.81
▸ MC1R Q01726 2/20 0.81
▸ CXCR4 P61073 7/20 0.68
▸ PTH1R Q03431 8/20 0.68
▸ C5AR1 P21730 1/20 0.65
▸ NPY1R P25929 1/20 0.64
▸ NPY2R P49146 1/20 0.64
▸ NPY4R P50391 1/20 0.64
▸ NPY5R Q15761 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cosyntropin SCHEMBL15960130 1.00 MC4R (0.81) MC4RMC5RMC3RMC1RCXCR4
Cosyntropin SCHEMBL29410267 1.00 MC4R (0.81) MC4RMC5RMC3RMC1RCXCR4
SCHEMBL29519503 0.97 MC4R (0.81) MC4RMC5RMC3RMC1RCXCR4
SCHEMBL31477752 0.97 MC4R (0.83) MC4RMC5RMC3RMC1RCXCR4
SCHEMBL29622934 0.97 MC4R (0.83) MC4RMC5RMC3RMC1RCXCR4
SCHEMBL29382991 0.96 MC4R (0.84) MC4RMC5RMC3RMC1RCXCR4
SCHEMBL29385997 0.96 MC4R (0.84) MC4RMC5RMC3RMC1RCXCR4
Tosactide SCHEMBL29353880 0.95 MC4R (0.77) MC4RMC5RMC3RMC1RCXCR4
Cosyntropin SCHEMBL28099341 0.95 MC4R (0.74) MC4RMC5RMC3RMC1RCXCR4
Alsactide SCHEMBL1649355 0.94 MC4R (0.84) MC4RMC5RMC3RMC1RCXCR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4027 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260124148-A1 POLYPEPTIDE FORMULATIONS FOR ORAL DELIVERY BHAMIS RES LABORATORY PVT LTD (IN) 2026-05-07 — — US claimed
EP-4728280-A1 COMPOUNDS FOR DIAGNOSING AND TREATING EPILEPSY SYNDROMES, METHODS AND USES THEREOF BIOSTRIKE UNIPESSOAL LDA (PT) 2026-04-22 — — EP claimed
US-20260027062-A1 IMPROVED ORAL PHARMACEUTICAL FORMULATIONS OF THERAPEUTIC PEPTIDES AND PROTEINS CYPRUMED GMBH (AT) 2026-01-29 — — US claimed
US-12533321-B2 Polypeptide formulations for oral delivery Bhami's Research Laboratory, Pvt. Ltd. (IN) 2026-01-27 — — US claimed
EP-4601697-A2 A FORMULATION FOR ORAL DELIVERY OF PEPTIDES AND BIOSIMILARS FOR SYSTEMIC ABSORPTION AND METHOD OF MANUFACTURING THE SAME NBI Biosciences Pvt Ltd (IN) 2025-08-20 — — EP claimed
EP-4601623-A1 POLYPEPTIDE FORMULATIONS FOR ORAL DELIVERY Bhami's Research Laboratory, Pvt. Ltd. (IN) 2025-08-20 — — EP claimed
US-20250231192-A1 DETECTION AND QUANTIFICATION OF ANTI-DRUG ANTIBODIES AND ANTI-SELF ANTIBODIES PROMISE PROTEOMICS (FR) 2025-07-17 — — US claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 — — WO claimed
US-20250152501-A1 DISSOLVING MICRONEEDLE FOR TRANSDERMAL DELIVERY OF BIOPHARMACEUTICAL, AND MANUFACTURING METHOD THEREFOR DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) 2025-05-15 — — US claimed
US-12208118-B2 Pharmaceutical compositions for delivery of peptide ANYA BIOPHARM INC. (CN) 2025-01-28 — — US claimed
WO-2001028555-A1 EMULSION COMPOSITIONS FOR POLYFUNCTIONAL ACTIVE INGREDIENTS LIPOCINE, INC. (US) 2001-04-26 — — WO claimed
WO-2001012155-A1 COMPOSITIONS AND METHODS FOR ENHANCED ABSORPTION OF HYDROPHILIC THERAPEUTIC AGENTS LIPOCINE, INC. (US) 2001-02-22 — — WO claimed
WO-2000013674-A1 DOSAGE FORM COMPRISING THERAPEUTIC FORMULATION ALZA CORPORATION (US) 2000-03-16 — — WO claimed
US-5499979-A Delivery system comprising kinetic forces ALZA CORPORATION (US) 1996-03-19 — — US claimed
EP-0491803-B1 IMPLANTABLE DELIVERY DISPENSER ALZA CORP (US) 1994-07-20 — — EP claimed
EP-0491803-A1 IMPLANTABLE DELIVERY DISPENSER. ALZA CORP (US) 1992-07-01 — — EP claimed
US-5112614-A IMPLANTABLE DELIVERY DISPENSER ALZA CORPORATION (US) 1992-05-12 — — US claimed
US-5023088-A Drug delivery dispenser ALZA CORPORATION (US) 1991-06-11 — — US claimed
WO-1991004016-A1 IMPLANTABLE DELIVERY DISPENSER ALZA CORPORATION (US) 1991-04-04 — — WO claimed
US-4957494-A Multi-layer delivery system ALZA CORPORATION (US) 1990-09-18 — — US claimed