⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4445826 | 0.98 | CYP2D6 (0.48) | — | |
| SCHEMBL27879164 | 0.96 | CYP2D6 (0.47) | — | |
| SCHEMBL447294 | 0.93 | — | — | |
| SCHEMBL27879161 | 0.85 | CYP2D6 (0.46) | — | |
| SCHEMBL6196925 | 0.85 | HRH3 (0.45) | — | |
| SCHEMBL28102358 | 0.83 | CYP2D6 (0.44) | — | |
| SCHEMBL2090140 | 0.83 | HRH3 (0.44) | — | |
| SCHEMBL27895920 | 0.81 | CYP2D6 (0.43) | — | |
| SCHEMBL27895901 | 0.81 | CYP2D6 (0.43) | — | |
| SCHEMBL200102 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6846827-B1 | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2005-01-25 | — | — | US | claimed |
| EP-1226126-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-01-05 | — | — | EP | claimed |
| EP-1226126-A1 | PYRIMIDINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-31 | — | — | EP | claimed |
| WO-2001027089-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-04-19 | — | — | WO | claimed |
| US-5378691-A | Amino acid derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-01-03 | — | — | US | claimed |
| CN-111492000-B | Rubber composition and tire using same | 株式会社普利司通 | 2023-02-17 | — | — | CN | disclosed |
| CN-110730801-B | Sidewall reinforcing rubber for run flat tire and run flat tire | 株式会社普利司通 | 2022-07-19 | — | — | CN | disclosed |
| CN-114502629-A | Safety tyre | 株式会社普利司通 | 2022-05-13 | — | — | CN | disclosed |
| CN-114466888-A | Rubber composition and run-flat tire | 株式会社普利司通 | 2022-05-10 | — | — | CN | disclosed |
| CN-111032369-B | Pneumatic tire | 株式会社普利司通 | 2022-04-15 | — | — | CN | disclosed |
| WO-2021066106-A1 | RUBBER COMPOSITION AND RUN-FLAT TIRE | 株式会社ブリヂストン | 2021-04-08 | — | — | WO | disclosed |
| WO-2021066099-A1 | RUN-FLAT TIRE | 株式会社ブリヂストン | 2021-04-08 | — | — | WO | disclosed |
| WO-2002016348-A1 | ANTIANGIOGENIC BICYCLIC DERIVATIVES | ASTRAZENECA AB (SE) | 2002-02-28 | — | — | WO | disclosed |
| WO-2002012228-A1 | CINNOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2002-02-14 | — | — | WO | disclosed |
| WO-2002012227-A2 | INDOLE, AZAINDOLE AND INDAZOLE DERIVATIVES HAVING VEGF INHIBITING ACTIVITY | ASTRAZENECA AB (SE) | 2002-02-14 | — | — | WO | disclosed |
| WO-2002012226-A1 | QUINOLINE DERIVATIVES HAVING VEGF INHIBITING ACTIVITY | ASTRAZENECA AB (SE) | 2002-02-14 | — | — | WO | disclosed |
| EP-1154774-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AstraZeneca AB (SE) | 2001-11-21 | — | — | EP | disclosed |
| WO-2001027089-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-04-19 | — | — | WO | disclosed |
| WO-2000047212-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2000-08-17 | — | — | WO | disclosed |
| US-4242507-A | Sulfonic acid esters | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-12-30 | — | — | US | disclosed |