Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 3/20 | 0.36 |
| ▸ | GP6 | Q9HCN6 | 3/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CCR6 | P51684 | 2/20 | 0.33 |
| ▸ | MMP8 | P22894 | 2/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | FNTA | P49354 | 1/20 | 0.32 |
| ▸ | FNTB | P49356 | 1/20 | 0.32 |
| ▸ | STAT1 | P42224 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
| ▸ | TUBB | P07437 | 1/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.32 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.32 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3340836 | 0.86 | HCRTR1 (0.37) | HCRTR1HCRTR2HTR6GP6PRMT5 | |
| SCHEMBL639664 | 0.83 | HCRTR1 (0.39) | HCRTR1HCRTR2HTR6PRMT5WDR77 | |
| SCHEMBL641893 | 0.82 | HCRTR1 (0.40) | HCRTR1HCRTR2PRMT5WDR77CHRM5 | |
| SCHEMBL639700 | 0.81 | HCRTR1 (0.39) | HCRTR1HCRTR2CHRM5CCR6FNTA | |
| SCHEMBL639854 | 0.81 | HCRTR1 (0.39) | HCRTR1HCRTR2CHRM5CCR6FNTA | |
| SCHEMBL639699 | 0.81 | HCRTR1 (0.39) | HCRTR1HCRTR2CHRM5CCR6FNTA | |
| SCHEMBL640384 | 0.80 | HCRTR1 (0.41) | HCRTR1HCRTR2CHRM5CCR6 | |
| SCHEMBL641102 | 0.80 | HCRTR1 (0.41) | HCRTR1HCRTR2CHRM5CCR6 | |
| SCHEMBL641101 | 0.80 | HCRTR1 (0.41) | HCRTR1HCRTR2CHRM5CCR6 | |
| SCHEMBL641338 | 0.78 | CCR6 (0.40) | HCRTR1HCRTR2PRMT5WDR77CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100152168-A1 | SUBSTITUTED BENZIMIDAZOLONE DERIVATIVES, MEDICAMENTS COMPRISING THEM AND THEIR USE | ABBOTT GMBH & CO. KG (DE) | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152168-A1 | SUBSTITUTED BENZIMIDAZOLONE DERIVATIVES, MEDICAMENTS COMPRISING THEM AND THEIR USE | AVPR2, AVPR1B, AVPR1A | HCRTR1 951/4885HCRTR2 641/4885HTR6 826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.