Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.43 |
| ▸ | HRH1 | P35367 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25298623 | 0.89 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3TSHRCYP1A2 | |
| SCHEMBL725091 | 0.88 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3TSHRCYP1A2 | |
| Ammonia Solution, Strong SCHEMBL7995788 | 0.86 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3TSHRCYP1A2 | |
| SCHEMBL17069296 | 0.80 | SLC6A2 (0.63) | SLC6A2SLC6A4SLC6A3TSHRCYP1A2 | |
| SCHEMBL17069299 | 0.80 | SLC6A2 (0.63) | SLC6A2SLC6A4SLC6A3TSHRCYP1A2 | |
| SCHEMBL3103040 | 0.80 | SLC6A2 (0.63) | SLC6A2SLC6A4SLC6A3TSHRCYP1A2 | |
| Ammonia Solution, Strong SCHEMBL6267830 | 0.78 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3TSHRCYP1A2 | |
| SCHEMBL29801709 | 0.78 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3TSHRCYP1A2 | |
| SCHEMBL29801749 | 0.78 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3TSHRCYP1A2 | |
| SCHEMBL79529 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100152219-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA R&D (SE) | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152219-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | LTK, ERBB2, ERBB3 | SLC6A2 4716/4885SLC6A4 4244/4885SLC6A3 4041/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.