Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.65 |
| ▸ | NPC1 | O15118 | 6/20 | 0.65 |
| ▸ | RAB9A | P51151 | 6/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | HPGD | P15428 | 6/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | GFER | P55789 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4373640 | 0.89 | KDM4E (0.69) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL28477377 | 0.86 | CYP11B1 (0.70) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL1170649 | 0.85 | KDM4E (0.52) | KDM4ENPC1RAB9ASMN1; SMN2CYP11B1 | |
| SCHEMBL17393597 | 0.84 | NR1H4 (0.51) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL29824674 | 0.84 | NPC1 (0.58) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL22955327 | 0.84 | NPC1 (0.58) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL3336522 | 0.83 | NPC1 (0.57) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL6247115 | 0.83 | SMN1; SMN2 (0.61) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL4184286 | 0.83 | CYP11B1 (0.67) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL10175464 | 0.83 | CYP11B1 (0.79) | KDM4ENPC1RAB9ASMN1; SMN2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110759903-B | Novel synthesis method of thiabendazole | 南开大学 | 2022-10-28 | — | — | CN | disclosed |
| US-20210371992-A1 | ELECTROCHEMICAL ORGANIC REACTION SETUP AND METHODS | PIRAMAL PHARMA LIMITED (IN) | 2021-12-02 | — | — | US | disclosed |
| CN-108129395-B | Organic electroluminescent material and preparation method and application thereof | 北京燕化集联光电技术有限公司 | 2020-09-15 | — | — | CN | disclosed |
| US-8198307-B2 | Imidazole derivatives having aryl piperidine substituent, method for preparation thereof and pharmaceutical compositions containing same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2012-06-12 | — | — | US | disclosed |
| US-20100145054-A1 | IMIDAZOLE DERIVATIVES HAVING ARYL PIPERIDINE SUBSTITUENT, METHOD FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100145054-A1 | IMIDAZOLE DERIVATIVES HAVING ARYL PIPERIDINE SUBSTITUENT, METHOD FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | TYR, MCHR1, MCHR2 | KDM4E 220/4885NPC1 223/4885RAB9A 687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.