Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.49 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.37 |
| ▸ | LPL | P06858 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | CTSV | O60911 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL639792 | 0.89 | GFER (0.50) | GFERKDM4EGAAHDAC8MAPT | |
| SCHEMBL638777 | 0.86 | GFER (0.58) | GFERKDM4EGAAHDAC8MAPT | |
| SCHEMBL638407 | 0.79 | GFER (0.58) | GFERKDM4EGAAHDAC8MAPT | |
| SCHEMBL639476 | 0.78 | GFER (0.53) | GFERKDM4EGAAHDAC8MAPT | |
| SCHEMBL3344780 | 0.76 | GAA (0.64) | GFERKDM4EGAAHDAC8MAPT | |
| SCHEMBL3342864 | 0.76 | CYP2D6 (0.54) | GFERKDM4EGAAHDAC8MAPT | |
| SCHEMBL2246977 | 0.74 | HDAC8 (0.36) | GFERKDM4EGAAHDAC8MAPT | |
| SCHEMBL2246970 | 0.72 | GFER (0.39) | GFERKDM4EGAAHDAC8MAPT | |
| SCHEMBL3343038 | 0.72 | GFER (0.64) | GFERKDM4EGAAHDAC8MAPT | |
| SCHEMBL3343853 | 0.72 | GFER (0.64) | GFERKDM4EGAAHDAC8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160401-A1 | 4-PHENYLIMIDAZOLE-2-THIONE TYROSINASE INHIBITORS AND TREATMENT OR PREVENTION OF PIGMENTARY DISORDERS THEREWITH | GALDERMA RESEARCH & DEVELOPMENT, BIOT, FRANCE | 2010-06-24 | — | — | US | claimed |
| US-20100160401-A1 | 4-PHENYLIMIDAZOLE-2-THIONE TYROSINASE INHIBITORS AND TREATMENT OR PREVENTION OF PIGMENTARY DISORDERS THEREWITH | GALDERMA RESEARCH & DEVELOPMENT, BIOT, FRANCE | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160401-A1 | 4-PHENYLIMIDAZOLE-2-THIONE TYROSINASE INHIBITORS AND TREATMENT OR PREVENTION OF PIGMENTARY DISORDERS THEREWITH | TYR, TH, PAH | GFER 2509/4885KDM4E 1018/4885GAA 58/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.