Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 13/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3344469 | 0.90 | HCRTR1 (0.50) | HCRTR1HCRTR2FPR2 | |
| SCHEMBL3344316 | 0.84 | HCRTR1 (0.46) | HCRTR1HCRTR2FPR2ALDH1A1KDM4E | |
| SCHEMBL2056723 | 0.80 | HCRTR1 (0.46) | HCRTR1HCRTR2FPR2ALDH1A1KDM4E | |
| SCHEMBL3344465 | 0.76 | HCRTR1 (0.51) | HCRTR1HCRTR2FPR2 | |
| SCHEMBL2636011 | 0.74 | HCRTR1 (0.44) | HCRTR1HCRTR2FPR2ALDH1A1KDM4E | |
| SCHEMBL3348074 | 0.72 | HCRTR1 (0.56) | HCRTR1HCRTR2 | |
| SCHEMBL3350904 | 0.72 | HCRTR1 (0.51) | HCRTR1HCRTR2 | |
| SCHEMBL2057193 | 0.70 | HCRTR1 (0.49) | HCRTR1HCRTR2FPR2 | |
| SCHEMBL1167223 | 0.70 | MAPK13 (0.50) | HCRTR1LMNAALDH1A1KDM4EMAPK13 | |
| SCHEMBL3343787 | 0.69 | HCRTR1 (0.51) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038200-A1 | OXAZOLIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-08 | — | — | WO | claimed |
| WO-2010038200-A1 | OXAZOLIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-08 | — | — | WO | disclosed |