Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 11/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2462030 | 1.00 | CASR (0.71) | CASRCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL3923302 | 0.82 | CASR (0.66) | CASRCLK4MAPK1 | |
| SCHEMBL3930540 | 0.82 | CASR (0.65) | CASRCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL3923428 | 0.81 | CASR (0.67) | CASRCLK4LMNAMAPK1HTT | |
| SCHEMBL3923099 | 0.81 | CASR (0.74) | CASRCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL15162367 | 0.80 | SMN1; SMN2 (0.58) | HSD17B10ALDH1A1TP53SMN1; SMN2HTT | |
| SCHEMBL3923152 | 0.80 | CASR (0.88) | CASRLMNAHTT | |
| SCHEMBL3959603 | 0.79 | CASR (0.75) | CASRCYP3A4ALDH1A1LMNAHTT | |
| SCHEMBL3920463 | 0.78 | CASR (0.58) | CASR | |
| SCHEMBL15130965 | 0.78 | CASR (0.82) | CASRALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042642-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. (US) | 2010-04-15 | — | — | WO | claimed |
| WO-2010042642-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. (US) | 2010-04-15 | — | — | WO | disclosed |